Can I take Aspirin and Spironolactone together?

Why this happens

Spironolactone works by helping your kidneys get rid of salt and water. Aspirin can block the chemical signals (prostaglandins) that the kidneys need to do this job effectively. Additionally, both drugs can affect how the kidneys filter blood, which can lead to a buildup of potassium or reduced kidney function.

What you should do

Use this combination with caution. If you are taking aspirin for pain relief, consider using paracetamol instead. If you are taking low-dose aspirin (75mg to 150mg) for heart protection, do not stop taking it, but ensure your doctor monitors your kidney function and potassium levels regularly. Seek medical advice if you notice swelling in your ankles or a decrease in how much you urinate.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.