Can I take Lixiana and Paracetamol together?

It is generally considered safe to take Lixiana and paracetamol together.

Lixiana is an anticoagulant (blood thinner) that works by blocking a specific clotting factor. Paracetamol works on the central nervous system to relieve pain and does not affect blood clotting or the way Lixiana is processed by the liver or kidneys.

How to take Lixiana and paracetamol safely

You should avoid anti-inflammatory painkillers such as ibuprofen or aspirin unless specifically prescribed by your doctor, as these can increase your risk of bleeding.

Important precautions

Bleeding risk

Lixiana increases your risk of serious bleeding. Seek immediate medical help if you have a fall or head injury, or if you notice signs of internal bleeding such as black tarry stools, blood in your urine, or coughing up blood.

Surgery or dental procedures

You must tell your doctor or dentist you are taking Lixiana before any procedure, as you may need to stop taking it temporarily to prevent dangerous bleeding.

Liver safety and combination products

Never exceed the maximum dose of paracetamol (usually 4g in 24 hours). Many over-the-counter cold and flu remedies also contain paracetamol; taking them alongside your prescribed dose can lead to fatal liver damage.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking paracetamol. Combining alcohol and paracetamol increases the risk of serious liver damage.

It is best to avoid or strictly limit alcohol while taking Lixiana. Alcohol can increase the risk of bleeding in your stomach and intestines. Additionally, heavy drinking can affect how your liver functions, which may interfere with how your body processes this medication.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.