Can I take Naproxen and Paracetamol together?

Why this happens

Naproxen and paracetamol work in different ways to block pain signals. Naproxen is a non-steroidal anti-inflammatory drug (NSAID) that reduces inflammation, while paracetamol works mainly in the central nervous system. Because they do not interfere with how the body processes (metabolises) each other, they can be used at the same time.

What you should do

You can take these medicines together, but ensure you do not exceed the maximum daily dose for either. Always take naproxen with food or a milky drink to protect your stomach. If you find you need to take this combination for more than a few days, speak to your pharmacist or GP to ensure there isn't an underlying issue that needs different treatment.

Important precautions

Asthma

Do not take naproxen if you have asthma that is sensitive to aspirin or other NSAIDs, as it can trigger a life-threatening asthma attack or severe breathing difficulties.

Stomach ulcers or bleeding

Naproxen can cause serious stomach ulcers and internal bleeding. This risk is higher if you have had ulcers before, are over 65, or take other blood-thinning medicines. Stop taking it and see a doctor immediately if you have black, tarry stools or vomit blood.

Liver health and overdose risk

Never exceed the maximum dose of paracetamol. Taking too much can cause fatal liver damage. Check all other cold and flu remedies to ensure they do not also contain paracetamol.

Pregnancy (third trimester)

Do not take naproxen if you are more than 20 weeks pregnant. It can cause serious kidney or heart problems in the unborn baby and may lead to complications during delivery.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking paracetamol. Combining alcohol and paracetamol increases the risk of serious liver damage.

It is best to avoid or strictly limit alcohol while taking naproxen. Both alcohol and naproxen can irritate the lining of your stomach; combining them significantly increases your risk of developing stomach ulcers or internal bleeding.

Food (General)

You should take naproxen with or just after a meal or a snack. This helps to protect your stomach lining and reduces the risk of indigestion or stomach pain.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.