Can I take Chaga and Royal sun together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Both Chaga (Inonotus obliquus) and Royal Sun (Agaricus blazei) are medicinal mushrooms that can lower blood sugar levels and thin the blood. Taking them together may increase the risk of your blood sugar dropping too low (hypoglycaemia) or increase the risk of bruising and bleeding.
Why this happens
These mushrooms have additive effects. Both contain compounds (like beta-glucans) that improve insulin sensitivity and others that may interfere with blood clotting (anti-platelet effects). Taking them together doubles up on these specific actions.
What you should do
Use this combination with caution. If you have diabetes or take blood-thinning medication (like warfarin or aspirin), you must speak to your doctor before combining these supplements. Monitor your blood sugar levels closely and watch for signs of easy bruising or nosebleeds. Stop taking both at least two weeks before any scheduled surgery.
Important precautions
Kidney disease or history of kidney stones
Chaga is extremely high in oxalates, which can cause permanent kidney damage or acute kidney failure, especially in those with existing renal issues.
Diabetes
Both mushrooms can significantly lower blood glucose levels. Using them alongside prescribed diabetes medication increases the risk of severe hypoglycaemia (dangerously low blood sugar).
Autoimmune diseases (e.g., Lupus, MS, Rheumatoid Arthritis)
Chaga can stimulate the immune system, which may worsen symptoms of autoimmune conditions or interfere with immunosuppressant medications.
Bleeding disorders or upcoming surgery
Chaga may slow blood clotting and increase the risk of bleeding; it should be avoided if you have a bleeding disorder or are scheduled for surgery.
Food and drink warnings
Alcohol
Chaga contains high levels of oxalates. Combining it with alcohol may increase the risk of kidney stones or kidney stress, as both substances can affect renal function. Use with caution.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Naproxen and Tramadol together?
Taking naproxen and tramadol together can increase the risk of serious side effects, particularly affecting your stomach and kidneys. There is also a small but important risk of seizures (fits) and a rare condition called serotonin syndrome. However, these two medicines are often prescribed together for short-term pain relief under medical supervision.

Drug interactions checker
Can I take Warfarin and Aspirin together?
Taking warfarin and aspirin together significantly increases your risk of serious bleeding. This includes internal bleeding, such as in the stomach or brain, as well as bleeding that is hard to stop from minor cuts or injuries.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
24 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amlodipine and Apixaban together?
- Can I take Amlodipine and Aspirin together?
- Can I take Amlodipine and Empagliflozin together?
- Can I take Amlodipine and Nustendi together?
- Can I take antihistamines with alcohol?
- Can I take Atorvastatin and Eplerenone together?
- Can I take Black garlic and Evening primrose oil together?
- Can I take Carbimazole and Collagen together?
- Can I take Danazol and Quetiapine together?
- Can I take Doxazosin and Evolocumab together?
- Can I take Evening primrose oil and Ginger together?
- Can I take Hydroxychloroquine and Naproxen together?
- Can I take Ibuprofen gel 10% and Oxycodone together?
- Can I take Indapamide and Vitamin C together?
- Can I take Lansoprazole and Tramadol together?
- Can I take Magnesium and Oestrogel pump-pack together?
- Can I take Maitake and Royal sun together?
- Can I take Nikethamide and Venlafaxine together?
- Can I take Sertraline and Vitamin D3 together?
- Can I take Sildenafil and Metformin together?