Can I take Chaga and Reishi together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Taking chaga and reishi together may significantly increase the risk of bruising or bleeding. Both mushrooms have 'blood-thinning' properties, meaning they can slow down how quickly your blood clots. Combining them can have an additive effect, making it harder for your body to stop bleeding if you are injured. Additionally, both may lower blood sugar levels, which could lead to symptoms of low blood sugar (hypoglycaemia) such as dizziness or shakiness.
Why this happens
Both chaga and reishi contain compounds that interfere with platelet aggregation (the way blood cells stick together to form clots). Chaga is also high in oxalates which can affect metabolism. Furthermore, both fungi possess hypoglycaemic properties, meaning they can both lower blood glucose through similar pathways in the body.
What you should do
Use caution when combining these supplements. If you are scheduled for surgery, stop taking both at least two weeks beforehand. You should consult your doctor before taking this combination if you are already taking prescribed blood thinners (like warfarin or aspirin), blood pressure medication, or diabetes medication. Monitor yourself for signs of unusual bruising, nosebleeds, or light-headedness.
Important precautions
Kidney disease or history of kidney stones
Chaga is extremely high in oxalates, which can cause permanent kidney damage or acute kidney failure, especially in those with existing renal issues.
Diabetes
These supplements can lower blood sugar levels; when combined with insulin or other diabetes medications, they may cause dangerously low blood sugar (hypoglycaemia).
Autoimmune diseases (e.g., Lupus, MS, Rheumatoid Arthritis)
Chaga can stimulate the immune system, which may worsen symptoms of autoimmune conditions or interfere with immunosuppressant medications.
Bleeding disorders or upcoming surgery
Both mushrooms can significantly thin the blood and increase the risk of bruising or dangerous bleeding; they must be stopped at least 2 weeks before any planned surgery.
Low blood pressure (hypotension)
Reishi can lower blood pressure and may cause it to drop too low if you already have low blood pressure or are taking medication to treat it.
Food and drink warnings
Alcohol
Chaga contains high levels of oxalates. Combining it with alcohol may increase the risk of kidney stones or kidney stress, as both substances can affect renal function. Use with caution.
Reishi may have a mild sedative effect or affect how your liver processes substances. Combining it with alcohol could potentially increase drowsiness or put extra strain on the liver. It is best to limit alcohol intake while taking this supplement.
Using other medicines?
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Ashwagandha and Vitamin B12 together?
There are no known clinical interactions between ashwagandha and vitamin B12. It is generally considered safe to take these two supplements together.

Drug interactions checker
Can I take Magnesium and Wegovy flextouch together?
There is no known direct interaction between magnesium supplements and Wegovy (semaglutide). However, both can affect your digestive system. Wegovy slows down how quickly your stomach empties, which could theoretically change how quickly your body absorbs magnesium, though this is rarely a clinical concern. Additionally, both can cause side effects like nausea or changes in bowel habits (magnesium often softens stools, while Wegovy can cause constipation or diarrhoea).
Article history
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
24 Jan 2026 | Originally published
Join the conversation
Share your thoughts or experiences with others in our patient communities.

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I give my child antihistamines?
- Can I take Allopurinol and Co-amoxiclav together?
- Can I take Amitriptyline and Pregabalin together?
- Can I take Amitriptyline and Zopiclone together?
- Can I take Amlodipine and Lansoprazole together?
- Can I take Amlodipine and Simvastatin together?
- Can I take Anastrozole and Venlafaxine together?
- Can I take Candesartan and Rosuvastatin together?
- Can I take Clopidogrel and Paracetamol together?
- Can I take Co-codamol and Stexerol D3 together?
- Can I take Danazol and Naproxen together?
- Can I take Escitalopram and Topiramate together?
- Can I take Esomeprazole and Pregabalin together?
- Can I take Esomeprazole and Vitamin C together?
- Can I take Fluanxol and Sedoxil together?
- Can I take Iron and Levothyroxine together?
- Can I take Mirtazapine and Paracetamol together?
- Can I take Pregabalin and Venlafaxine together?
- Can I take Warfarin and Methotrexate together?