Can I take Chaga and Reishi together?
Drug interaction guide
Originally published 24 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Taking chaga and reishi together may significantly increase the risk of bruising or bleeding. Both mushrooms have 'blood-thinning' properties, meaning they can slow down how quickly your blood clots. Combining them can have an additive effect, making it harder for your body to stop bleeding if you are injured. Additionally, both may lower blood sugar levels, which could lead to symptoms of low blood sugar (hypoglycaemia) such as dizziness or shakiness.
Why this happens
Both chaga and reishi contain compounds that interfere with platelet aggregation (the way blood cells stick together to form clots). Chaga is also high in oxalates which can affect metabolism. Furthermore, both fungi possess hypoglycaemic properties, meaning they can both lower blood glucose through similar pathways in the body.
What you should do
Use caution when combining these supplements. If you are scheduled for surgery, stop taking both at least two weeks beforehand. You should consult your doctor before taking this combination if you are already taking prescribed blood thinners (like warfarin or aspirin), blood pressure medication, or diabetes medication. Monitor yourself for signs of unusual bruising, nosebleeds, or light-headedness.
Important precautions
Kidney disease or history of kidney stones
Chaga is extremely high in oxalates, which can cause permanent kidney damage or acute kidney failure, especially in those with existing renal issues.
Diabetes
These supplements can lower blood sugar levels; when combined with insulin or other diabetes medications, they may cause dangerously low blood sugar (hypoglycaemia).
Autoimmune diseases (e.g., Lupus, MS, Rheumatoid Arthritis)
Chaga can stimulate the immune system, which may worsen symptoms of autoimmune conditions or interfere with immunosuppressant medications.
Bleeding disorders or upcoming surgery
Both mushrooms can significantly thin the blood and increase the risk of bruising or dangerous bleeding; they must be stopped at least 2 weeks before any planned surgery.
Low blood pressure (hypotension)
Reishi can lower blood pressure and may cause it to drop too low if you already have low blood pressure or are taking medication to treat it.
Food and drink warnings
Alcohol
Chaga contains high levels of oxalates. Combining it with alcohol may increase the risk of kidney stones or kidney stress, as both substances can affect renal function. Use with caution.
Reishi may have a mild sedative effect or affect how your liver processes substances. Combining it with alcohol could potentially increase drowsiness or put extra strain on the liver. It is best to limit alcohol intake while taking this supplement.
Using other medicines?
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Flecainide and Wegovy together?
Wegovy (semaglutide) can slow down how quickly your stomach empties. This might change how your body absorbs flecainide, which is a medicine that needs to be kept at very specific levels in your blood to work safely and effectively. Additionally, both medications can occasionally affect your heart rhythm or heart rate.

Drug interactions checker
Can I take Lisinopril and Potassium together?
Taking lisinopril and potassium supplements together can cause the levels of potassium in your blood to become dangerously high (a condition called hyperkalaemia). While your body needs potassium for your heart and muscles to work, too much of it can lead to serious heart rhythm problems or even cause the heart to stop. Symptoms of high potassium can include muscle weakness, tingling sensations, or palpitations, but often there are no symptoms until the level is very high.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
24 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amitriptyline and Naproxen together?
- Can I take Atorvastatin and Levothyroxine together?
- Can I take Atorvastatin and Paracetamol together?
- Can I take Atorvastatin and Rybelsus (semaglutide) together?
- Can I take Betahistine and Citalopram together?
- Can I take Bisoprolol and Fibre supplements together?
- Can I take Colecalciferol and Evolocumab together?
- Can I take Colecalciferol and Levothyroxine together?
- Can I take Colecalciferol and Trazodone together?
- Can I take Danazol and Metformin together?
- Can I take Flecainide and Rivaroxaban together?
- Can I take Fluanxol and Wellbutrin together?
- Can I take Folic acid and Vitamin B2 together?
- Can I take Ibuprofen and Amoxicillin together?
- Can I take Omeprazole and Ramipril together?
- Can I take Royal sun and Shiitake together?
- Can I take Solifenacin and Vitamin C together?
- Can I take Solifenacin and Vitamin D together?
- Can I take Vitamin D3 and Clopidogrel together?
- Can I take Warfarin and Ibuprofen together?