Can I take Betahistine and Citalopram together?

Why this happens

These medicines work in different ways and are processed by different pathways in the body. Betahistine acts on histamine receptors in the inner ear to treat vertigo, while citalopram increases serotonin levels in the brain to treat depression or anxiety. They do not interfere with each other's absorption or metabolism.

You can take both medicines as prescribed by your doctor. As with any new combination, monitor how you feel and speak to your pharmacist or GP if you notice any unusual side effects, such as increased dizziness or nausea.

Depression and anxiety disorders

You may experience an increase in suicidal thoughts or the urge to self-harm when first starting this medicine or changing the dose. This is more common in young adults under 25. Contact your doctor or go to hospital immediately if this happens.

Asthma

Betahistine can cause narrowing of the airways, which may worsen asthma symptoms or cause breathing difficulties. Patients with asthma should be closely monitored.

Peptic Ulcer Disease

Betahistine can increase stomach acid production, which may worsen existing stomach ulcers or cause them to recur. Use with caution if you have a history of indigestion or ulcers.

Heart Rhythm Disorders (Long QT Syndrome)

Citalopram can affect the electrical activity of the heart. It must be avoided if you have a heart rhythm problem called 'long QT syndrome' or if you are taking other medicines that affect heart rhythm.

Bleeding disorders

Citalopram increases your risk of bleeding, particularly in the stomach. Use with caution if you take blood-thinning medicines (like warfarin) or anti-inflammatory painkillers (like ibuprofen or aspirin).

Serotonin Syndrome

Taking citalopram with other medicines that increase serotonin (such as St John’s Wort, tramadol, or other antidepressants) can cause a life-threatening condition called serotonin syndrome. Symptoms include high fever, agitation, confusion, and muscle twitching.

Low sodium levels (Hyponatraemia)

Citalopram can cause a serious drop in blood sodium levels, especially in the elderly. Seek medical help if you experience extreme tiredness, confusion, or muscle twitching.

Alcohol

While alcohol does not have a direct chemical interaction with citalopram, it is generally advised to avoid drinking alcohol while taking antidepressants. Alcohol can worsen depression and increase the sedative side effects (drowsiness or dizziness) of the medication.

Caffeine (Coffee, Tea, Energy Drinks)

Citalopram can sometimes cause feelings of restlessness or jitteriness, especially when you first start taking it. Caffeine is a stimulant that can worsen these side effects and may increase feelings of anxiety. It is advisable to monitor your caffeine intake.

Food (General)

You should ideally take betahistine with or after a meal. This helps to prevent minor stomach upsets, which are a common side effect of this medicine.

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.