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Can I take Aspirin and Furosemide together?

Drug interaction guide

Taking aspirin and furosemide together can make the furosemide (water tablet) less effective at removing excess fluid from your body. Additionally, at high doses of aspirin, there is an increased risk of kidney problems and a build-up of aspirin in your blood, which can lead to side effects like ringing in the ears (tinnitus).

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Why this happens

Both drugs compete to be cleared out of the body by the kidneys. Aspirin can block the kidneys from responding to furosemide, meaning you don't pass as much urine. Furthermore, because they use the same 'exit route' in the kidneys, taking them together can slow down how quickly aspirin leaves your system.

What you should do

If you are taking low-dose aspirin (75mg to 150mg) for heart protection, the interaction is usually small, but you should still have your kidney function and blood pressure monitored by your GP. Avoid taking high-dose aspirin (for pain or fever) while on furosemide. If you notice increased swelling in your ankles, shortness of breath, or ringing in your ears, contact your doctor.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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