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Can I take Apixaban and Fibre supplements together?

Drug interaction guide

Taking fibre supplements at the same time as apixaban might lower the amount of medicine your body absorbs. This could potentially make apixaban less effective at preventing blood clots.

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Why this happens

Fibre supplements (like psyllium husk or methylcellulose) work by absorbing water and forming a gel-like substance in the gut. This bulk can trap medication molecules or speed up their passage through the digestive system, reducing the time the body has to absorb the drug into the bloodstream.

What you should do

To be safe, take your apixaban at least 2 hours before or 2 hours after taking a fibre supplement. This gap ensures the fibre does not interfere with the absorption of your medication. Do not stop taking your prescribed medication without speaking to your doctor or pharmacist.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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