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Can I take Levothyroxine and Omeprazole together?

Drug interaction guide

Taking omeprazole may make your levothyroxine less effective. This could lead to symptoms of an underactive thyroid, such as feeling tired, cold, or gaining weight, even though you are taking your medication.

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Why this happens

Levothyroxine needs a highly acidic environment in the stomach to be absorbed properly into your body. Omeprazole works by reducing stomach acid, which can prevent the levothyroxine from dissolving and entering your bloodstream effectively.

What you should do

You should ideally take levothyroxine on an empty stomach, at least 30 to 60 minutes before breakfast or taking other medications like omeprazole. If you are starting, stopping, or changing your dose of omeprazole, tell your doctor. They may need to perform a blood test (TSH test) to check if your levothyroxine dose needs adjusting.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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