Can I take Naproxen and Tramadol together?

Why this happens

Naproxen is an anti-inflammatory (NSAID) and tramadol is an opioid-like painkiller. Both can irritate the stomach lining, increasing the risk of ulcers or bleeding. Both drugs also affect how the kidneys filter blood. Additionally, tramadol can lower the 'seizure threshold' (making a fit more likely), and while naproxen doesn't directly cause this, the combination of pain and multiple medications can increase overall physical stress.

What you should do

You can take these together if your doctor has specifically prescribed both, but you should use the lowest dose for the shortest time possible. Always take them with food to protect your stomach. Seek medical help immediately if you experience severe stomach pain, black/tarry stools, or if you feel unusually dizzy or confused. If you have a history of epilepsy, kidney problems, or stomach ulcers, talk to your pharmacist or doctor before combining them.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.