Can I take Tramadol and Venlafaxine together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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Taking these two medicines together significantly increases the risk of a rare but serious condition called 'serotonin syndrome'. This occurs when there is too much of a chemical called serotonin in your brain. Symptoms can include feeling very agitated, confused, or shaky, as well as sweating, a fast heartbeat, muscle twitching, or diarrhoea. In rare cases, this combination can also increase the risk of having a seizure (a fit).
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Why this happens
Both tramadol and venlafaxine increase the levels of serotonin in the brain. When used together, these effects add up, potentially leading to dangerously high levels. Additionally, both drugs can lower the 'seizure threshold', making it easier for the brain to experience a seizure.
What you should do
You should speak to your doctor before taking these medicines together. They may prefer to prescribe an alternative painkiller or antidepressant. If your doctor decides you must take both, they will monitor you closely. Seek immediate medical help if you experience high fever, shivering, severe muscle stiffness, or confusion.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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