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Can I take Empagliflozin and Metformin together?

Drug interaction guide

Taking these two medicines together can increase the risk of low blood sugar (hypoglycaemia) and a rare but serious condition called ketoacidosis. You may also experience more frequent urination or a higher risk of dehydration.

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Why this happens

Both medicines work in different ways to lower your blood sugar. Metformin reduces the amount of sugar your liver produces, while empagliflozin helps your kidneys remove sugar through your urine. Because they both lower blood sugar, their effects are added together. Empagliflozin also causes you to lose more fluid, which can lead to dehydration.

What you should do

It is very common for these two medicines to be prescribed together (sometimes in a single tablet). You should monitor your blood sugar levels regularly as advised by your doctor. Stay well-hydrated by drinking plenty of water. Seek medical help immediately if you feel very sick, have stomach pain, or notice a fruity smell on your breath, as these can be signs of ketoacidosis.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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