Can I take Royal sun and White button together?
Drug interaction guide
Originally published 25 Jan 2026
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Both Royal Sun (Agaricus blazei) and White Button mushrooms contain compounds that may lower blood sugar levels. Taking them together could potentially cause your blood sugar to drop too low (hypoglycaemia). Additionally, both mushrooms may have mild blood-thinning effects, which could slightly increase the risk of bruising or bleeding if taken in large amounts.
Why this happens
These mushrooms contain beta-glucans and other compounds that can improve insulin sensitivity or mimic insulin-like effects. They also contain substances that may interfere with how blood cells (platelets) clump together to form clots.
What you should do
It is generally safe to eat these as part of a normal diet. However, if you are taking them as concentrated supplements, you should monitor your blood sugar levels closely, especially if you have diabetes. If you notice symptoms like dizziness, shakiness, or unusual bruising, speak to your doctor. Stop taking high-dose supplements at least two weeks before any scheduled surgery.
Important precautions
Bleeding disorders or surgery
These supplements may slow blood clotting and increase the risk of bleeding. You must stop taking these at least 2 weeks before any scheduled surgery. Use with caution if you are taking blood-thinning medications like warfarin or aspirin.
Diabetes
These supplements can lower blood sugar levels. If you are taking insulin or other diabetes medications, monitor your blood sugar closely as your dose may need adjustment to prevent hypoglycaemia (dangerously low blood sugar).
Auto-immune conditions (e.g., multiple sclerosis, lupus, rheumatoid arthritis)
These supplements can increase immune system activity, which may worsen the symptoms of autoimmune diseases. Avoid use if you have these conditions.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking medicinal mushrooms. Both alcohol and certain compounds in these mushrooms are processed by the liver; combining them may increase the strain on your liver or alter how the supplements are metabolised.
General Food Intake
These medicinal mushrooms contain complex polysaccharides (beta-glucans). For the best absorption, it is often recommended to take them on an empty stomach, at least 30 minutes before a meal, or with a small amount of Vitamin C (such as a small glass of orange juice) which may help the body absorb the active compounds.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

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