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Can I take Amoxicillin and Clarithromycin together?

Drug interaction guide

There is no harmful interaction between amoxicillin and clarithromycin. In fact, these two antibiotics are very commonly prescribed together to treat certain types of infections, such as stomach ulcers caused by H. pylori bacteria or severe pneumonia.

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Why this happens

Amoxicillin (a penicillin) and clarithromycin (a macrolide) work in different ways to kill bacteria. Amoxicillin attacks the bacterial cell wall, while clarithromycin stops the bacteria from making proteins. Because they attack the infection from two different angles, they can be more effective when used together.

What you should do

It is safe to take these medicines together as prescribed by your doctor. Ensure you finish the full course of both antibiotics, even if you start to feel better. If you experience severe diarrhoea or a skin rash, contact your doctor.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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