Can I take Paracetamol and Rosuvastatin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known significant interaction between paracetamol and rosuvastatin. It is generally considered safe to take these two medicines together at the recommended doses.
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Why this happens
Paracetamol and rosuvastatin are processed by different pathways in the liver and do not interfere with how the body absorbs, breaks down, or removes either drug.
What you should do
You can take paracetamol while you are on rosuvastatin. Always follow the dosage instructions on the packet for paracetamol and do not exceed the maximum daily dose. If you experience unusual muscle pain, tenderness, or weakness while taking rosuvastatin, you should contact your doctor, regardless of whether you are taking paracetamol.
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Important precautions
Pregnancy
You must not take this medicine if you are pregnant or planning to become pregnant, as it may harm the unborn baby. Use effective contraception while taking it.
Liver disease or chronic alcohol use
Taking more than the recommended dose can cause fatal liver damage. Do not take any other products containing paracetamol at the same time.
Unexplained muscle pain
Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness, as this can rarely lead to serious kidney problems.
Food and drink warnings
Alcohol
Drinking large amounts of alcohol while taking rosuvastatin can increase your risk of developing serious liver problems. It is best to avoid excessive drinking (binge drinking) and stay within the recommended weekly limits.
Grapefruit juice
Unlike some other statins, rosuvastatin is not significantly affected by grapefruit juice. You can consume it in normal amounts, though it is always best to avoid drinking very large quantities (more than a litre a day).
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Taking these two medicines together can significantly increase the amount of rosuvastatin in your blood. This increases the risk of serious muscle damage (rhabdomyolysis), which can lead to kidney problems. Symptoms to watch for include unexplained muscle pain, tenderness, or weakness, especially if you also feel generally unwell or have a fever.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
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