Can I take Clopidogrel and Fenofibrate together?

Why this happens

Both medications can affect how your blood clots. Clopidogrel stops platelets from sticking together, while fenofibrate can sometimes increase the effects of blood-thinning processes in the body. Additionally, fenofibrate may slightly interfere with the enzymes in the liver that activate clopidogrel, though this effect is generally considered small.

What you should do

You can usually take these medicines together, but you should be alert for any unusual signs. Contact your doctor if you notice unexplained bruising, nosebleeds, blood in your urine or stools, or if a small cut takes a very long time to stop bleeding. Do not stop taking either medication without consulting your healthcare provider.

Important precautions

Muscle problems (Myopathy/Rhabdomyolysis) - fenofibrate

You must contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness. The risk is higher if you also take a 'statin' medicine or have kidney problems.

Pancreatitis - fenofibrate

Seek urgent medical help if you develop severe stomach pain that reaches through to your back, as this may be a sign of an inflamed pancreas.

Surgery or dental work

You must tell any surgeon, anaesthetist, or dentist that you are taking clopidogrel. You may need to stop taking it 7 days before any planned procedure to prevent excessive bleeding.

Stomach ulcers or bleeding disorders

Do not take clopidogrel if you have an active stomach ulcer or any condition causing active bleeding. Seek urgent medical help if you notice signs of internal bleeding, such as black, tarry stools or vomiting blood.

Food and drink warnings

Alcohol

Drinking alcohol while taking clopidogrel can increase the risk of bleeding in your stomach and intestines. It is best to limit your alcohol intake.

It is advisable to limit or avoid alcohol while taking fenofibrate. Both alcohol and fenofibrate can affect your liver, and combining them may increase the risk of liver damage. Additionally, alcohol can raise triglyceride levels, which may counteract the purpose of the medication.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.