Can I take Losartan and Pregabalin together?

Why this happens

This is a 'pharmacodynamic' interaction, meaning the drugs have different ways of working but produce similar side effects. Losartan lowers blood pressure, while pregabalin can cause dizziness and sedation as it affects the nervous system. When combined, these effects can add up. Additionally, both drugs are occasionally linked to peripheral oedema (fluid swelling).

What you should do

It is generally safe to take these together, but you should be cautious, especially when starting the combination or increasing the dose. Avoid driving or operating machinery until you know how the mix affects you. To prevent dizziness, try to stand up slowly from a sitting or lying position. If you notice significant swelling in your ankles or feel unusually faint, contact your doctor.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.