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Can I take Cannabis and Paracetamol together?

Drug interaction guide

There are no known significant interactions between cannabis and paracetamol. It is generally considered safe to use them together at recommended doses.

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Why this happens

Paracetamol and the main compounds in cannabis (THC and CBD) are processed by different pathways in the liver. They do not significantly interfere with how the body absorbs, breaks down, or removes each other. Additionally, they work on different systems in the body to relieve pain, so they do not typically cause dangerous additive side effects.

What you should do

You can take paracetamol while using cannabis, but always stick to the recommended dose of paracetamol (usually no more than 4g or eight 500mg tablets in 24 hours). If you are using cannabis for medicinal purposes, it is best to inform your doctor or pharmacist so they can monitor your overall pain management plan.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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