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Can I take Cod liver oil and Lixiana together?

Drug interaction guide

Taking cod liver oil with Lixiana (edoxaban) may increase your risk of bruising or bleeding. This could include nosebleeds, bleeding gums, or, in more serious cases, internal bleeding.

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Why this happens

Lixiana is an anticoagulant (blood thinner) that prevents clots. Cod liver oil contains omega-3 fatty acids, which also have a mild blood-thinning effect by making platelets (the cells that help blood clot) less sticky. When used together, these two effects can add up, making it harder for your blood to clot if you are injured.

You should speak to your doctor or pharmacist before combining these. If you do take both, watch closely for signs of unusual bleeding, such as blood in your urine or stools, dark tarry stools, or bruises that appear for no reason. If you have a fall or hit your head, seek medical advice even if you feel fine.

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Pregnancy and breastfeeding

Do not take cod liver oil if you are pregnant or planning to become pregnant. It contains high levels of Vitamin A (retinol), which can harm the development of an unborn baby.

Do not take Lixiana if you are pregnant or breastfeeding, as it may cause serious harm to the baby. Use effective contraception while taking it.

Bleeding risk

Taking cod liver oil with Lixiana can increase your risk of serious bleeding. Cod liver oil has mild blood-thinning properties that can add to the effect of your anticoagulant medication.

Surgery or dental procedures

You must tell your doctor or dentist you are taking Lixiana before any surgery or dental procedure, as it increases your risk of serious bleeding. Do not stop taking it without medical advice, as this increases your risk of a stroke.

Alcohol

It is best to avoid or strictly limit alcohol when taking cod liver oil. Both alcohol and high doses of vitamin A (found in cod liver oil) can put strain on the liver; combining them may increase the risk of liver toxicity.

It is best to avoid or strictly limit alcohol while taking Lixiana. Alcohol can increase the risk of bleeding in your stomach and intestines. Additionally, heavy drinking can affect how your liver functions, which may interfere with how your body processes this medication.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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