Can I take Simvastatin and Vitamin d together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Taking vitamin D supplements alongside simvastatin may slightly reduce the amount of simvastatin that stays in your bloodstream. However, this is generally not considered harmful and may actually help reduce some side effects of the statin.
In this article:
Continue reading below
Why this happens
Vitamin D and simvastatin are both processed by the same enzyme in the liver (CYP3A4). High doses of vitamin D might speed up this enzyme, causing the body to break down simvastatin a bit faster than usual. Conversely, some studies suggest vitamin D helps prevent the muscle aches sometimes caused by statins.
What you should do
You can safely take these together. You do not need to change your dose, but it is always good practice to inform your doctor or pharmacist about any supplements you are taking. If you notice your cholesterol levels rising or experience unusual muscle pain, speak with your GP.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Esomeprazole and Vitamin c together?
Esomeprazole may slightly reduce how much Vitamin C your body absorbs, but this is generally not a cause for concern for most people.

Treatment and medication
Can I take Apixaban and Sertraline together?
Taking these two medicines together can increase your risk of bleeding. This includes bruising more easily, nosebleeds, or more serious internal bleeding.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.