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Can I take Simvastatin and Vitamin d together?

Drug interaction guide

Taking vitamin D supplements alongside simvastatin may slightly reduce the amount of simvastatin that stays in your bloodstream. However, this is generally not considered harmful and may actually help reduce some side effects of the statin.

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Why this happens

Vitamin D and simvastatin are both processed by the same enzyme in the liver (CYP3A4). High doses of vitamin D might speed up this enzyme, causing the body to break down simvastatin a bit faster than usual. Conversely, some studies suggest vitamin D helps prevent the muscle aches sometimes caused by statins.

What you should do

You can safely take these together. You do not need to change your dose, but it is always good practice to inform your doctor or pharmacist about any supplements you are taking. If you notice your cholesterol levels rising or experience unusual muscle pain, speak with your GP.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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