Can I take Simvastatin and Vitamin B12 together?

Why this happens

Simvastatin is a cholesterol-lowering medication (statin) processed primarily by the liver, while vitamin B12 is a water-soluble vitamin absorbed in the gut and used for nerve and blood health. They do not interfere with each other's absorption, metabolism, or effectiveness.

What you should do

You can continue taking both as prescribed. You do not need to separate the doses or change the time of day you take them. Always inform your doctor or pharmacist of all supplements you are taking.

Important precautions

Pregnancy

Do not take simvastatin if you are pregnant, planning to become pregnant, or breastfeeding, as it may harm the developing baby. Use effective contraception while taking this medicine.

Muscle problems (Myopathy/Rhabdomyolysis)

Contact your doctor immediately if you experience unexplained muscle pain, tenderness, or weakness. This risk is significantly increased if you drink large amounts of grapefruit juice or take certain other medicines.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking simvastatin. Both alcohol and simvastatin can affect your liver; combining them increases the risk of liver damage and may also increase the risk of muscle side effects.

It is best to avoid or strictly limit alcohol while taking Vitamin B12. Heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut and can reduce the amount of the vitamin stored in the liver.

Grapefruit and Grapefruit Juice

You must avoid eating grapefruit or drinking grapefruit juice while taking simvastatin. Grapefruit contains compounds that increase the level of simvastatin in your blood, which significantly increases your risk of serious side effects, such as muscle damage (rhabdomyolysis).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.