Can I take Vitamin B2 and Vitamin D together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known negative interaction between vitamin B2 (riboflavin) and vitamin D. In fact, they are often taken together in multivitamin supplements.
Why this happens
Vitamin B2 and vitamin D are processed by the body through different pathways. Vitamin B2 is water-soluble and primarily excreted through urine, while vitamin D is fat-soluble and stored in the body's fatty tissues and liver. They do not compete for absorption or interfere with how the other works.
What you should do
It is safe to take vitamin B2 and vitamin D together. Always follow the dosage instructions on the product packaging or those provided by your healthcare professional. Taking vitamin D with a meal containing some fat can help your body absorb it better.
Important precautions
Hypercalcaemia (high blood calcium)
Do not take vitamin D if you have high levels of calcium in your blood or urine, as it can lead to serious kidney damage and heart rhythm problems.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking Vitamin B2. Alcohol can interfere with the way your body absorbs this vitamin from the digestive tract, making the supplement less effective.
High-fat meals
Vitamin D is fat-soluble. It is best absorbed when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy). Taking it on an empty stomach may reduce how much your body absorbs.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Warfarin and Ibuprofen together?
Taking ibuprofen while on warfarin significantly increases your risk of serious bleeding, particularly in the stomach or gut. This combination can cause internal bleeding that may be difficult to stop.

Drug interactions checker
Can I take Losartan and Vitamin D together?
There is no known direct interaction between losartan and vitamin D supplements. Taking these two together is generally considered safe.
Article history
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published
Join the conversation
Share your thoughts or experiences with others in our patient communities.

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amitriptyline and Gabapentin together?
- Can I take Amitriptyline and Trazodone together?
- Can I take Amoxicillin and Clarithromycin together?
- Can I take Apixaban and Metformin together?
- Can I take Apixaban and Sertraline together?
- Can I take Aspirin and Lansoprazole together?
- Can I take Atorvastatin and Mirabegron together?
- Can I take Atorvastatin and Royal sun together?
- Can I take Black cohosh and Vitamin D together?
- Can I take Candesartan and Mirtazapine together?
- Can I take Colecalciferol and Prednisolone together?
- Can I take Colecalciferol and Pregabalin together?
- Can I take Fexofenadine and Sertraline together?
- Can I take Flecainide and Wegovy together?
- Can I take Fluanxol and Iron supplements together?
- Can I take Lansoprazole and Tamsulosin together?
- Can I take Methotrexate and Ibuprofen together?
- Can I take Omeprazole and Ibuprofen together?
- Can I take Omeprazole and Ramipril together?
- Can I take Vitamin B12 and Vitamin C together?