Can I take Vitamin b12 and Vitamin d together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There is no known negative interaction between Vitamin B12 and Vitamin D. In fact, they are often taken together to support overall health.
In this article:
Continue reading below
Why this happens
These two vitamins are processed by the body through different pathways. Vitamin B12 is a water-soluble vitamin absorbed mainly in the small intestine with the help of a protein called intrinsic factor. Vitamin D is a fat-soluble vitamin that requires dietary fat for absorption. They do not compete for absorption or interfere with how the other is broken down or used by the body.
What you should do
It is safe to take Vitamin B12 and Vitamin D at the same time. You do not need to space them apart. For best results, Vitamin D should be taken with a meal containing some fat (like yoghurt, eggs, or avocado) to help your body absorb it properly. Always follow the dosage instructions on the label or those provided by your healthcare professional.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Esomeprazole and Trazodone together?
Esomeprazole may reduce the amount of trazodone that your body absorbs. This could potentially make trazodone less effective at treating your symptoms (such as depression or sleep issues). Additionally, both medications can rarely affect the electrical activity of your heart, though this risk is generally low.

Treatment and medication
Can I take Clarithromycin and Rosuvastatin together?
Taking these two medicines together can significantly increase the amount of rosuvastatin in your blood. This increases the risk of serious muscle damage (rhabdomyolysis), which can lead to kidney problems. Symptoms to watch for include unexplained muscle pain, tenderness, or weakness, especially if you also feel generally unwell or have a fever.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.