Can I take St john's wort and Vitamin d together?
Drug interaction guide
Originally published 25 Jan 2026
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St John's Wort may lower the levels of Vitamin D in your body, potentially leading to a deficiency. This means your Vitamin D supplement might not work as well as it should to support your bone health and immune system.
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Why this happens
St John's Wort is a 'liver enzyme inducer'. It speeds up the proteins (specifically CYP3A4) in your liver that break down medications and vitamins. This causes Vitamin D to be cleared from your system much faster than normal.
What you should do
If you are taking both, you should speak to your GP. They may want to monitor your Vitamin D levels with a blood test or suggest increasing your Vitamin D dose. Do not stop taking prescribed medication without consulting your doctor first.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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