Latest studies
- Active not recruitingPHASE3
A Study To Assess Adverse Events and Effectiveness of Upadacitinib Oral Tablets in Adult and Adolescent Participants With Vitiligo
This study looks into a new tablet medicine, upadacitinib, for adults and teenagers with a type of vitiligo. Researchers want to see how safe it is and how well it helps improve skin when compared to a dummy pill or light therapy.
VitiligoFrance - RecruitingNA
Effect of Agonist GLP1 on Adipose Tissue in Patients Undergoing Bariatric Surgery
This study looks at how a medicine called GLP-1 (used for weight loss) affects body fat in people having weight-loss surgery. Researchers want to see if GLP-1 changes levels of a hormone called oxytocin, which might help understand how these treatments work.
ObesityFrance - AuthorisedTherapeutic use (Phase IV)
PREP-ANCA - Comparison of a strategy based on clinic-biological surveillance versus pre-emptive treatment with rituximab in the event of ANCA (anti-neutrophil cytoplasm antibodies) repositivation in patients with granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA)
This study compares two ways to manage two rare conditions: granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). It looks at whether closely watching patients or giving them a treatment called rituximab early helps prevent their condition from flaring up again.
granulomatosis with polyangiitis and microscopic polyangiitisFrance - Active not recruitingPHASE3
A Study to Evaluate the Efficacy and Safety of Ocrelizumab in Adults With Primary Progressive Multiple Sclerosis
This study is looking at a new treatment called Ocrelizumab for primary progressive multiple sclerosis (PPMS). It compares Ocrelizumab to a dummy drug (placebo) to see how safe and effective it is for adults, including those who have had PPMS for a while.
Multiple Sclerosis, Primary ProgressiveFrance - RecruitingPHASE3
A Clinical Study of the Anti-cancer Effects of an Investigational Therapy or Chemotherapy in Patients With Recurring Uterine Cancer
This study is looking at a new treatment (BNT323) for women with advanced womb cancer that has come back. It compares BNT323 to standard chemotherapy to see if it works better at shrinking tumours and keeping the cancer from growing.
Endometrial CancerFrance - RecruitingPHASE3
A Study to Evaluate the Efficacy and Safety of DNTH103 in Adults With Chronic Inflammatory Demyelinating Polyneuropathy (CAPTIVATE)
This study looks at a new drug, claseprubart, for Chronic Inflammatory Demyelinating Polyneuropathy (CIDP). It aims to see if the drug helps people with CIDP and if it's safe. Some participants will receive the drug, and others a dummy treatment.
Chronic Inflammatory Demyelinating PolyneuropathyFrance - RecruitingPHASE1, PHASE2
A Study of YL201 in Patients With Advanced Solid Tumors
This study is testing a new medicine, YL201, for people with advanced cancers that haven't responded to other treatments. It will check if YL201 is safe and how well it works, sometimes given alongside another medicine called atezolizumab. It's an early-stage study happening in China and the US.
Advanced Solid TumorFrance - AuthorisedTherapeutic exploratory (Phase II)
INCREDIBLE: INCREmental DIalysis and diet for a Better Life Experience; Clinical relevance of an “add-on” Ketosteril supplementation on incremental haemodialysis period in incident haemodialysis patients. An exploratory randomized controlled trial
This study looks at people with kidney failure starting dialysis less often (incremental haemodialysis). It checks if a medicine called Ketosteril, along with diet changes, can help extend this period before needing more frequent dialysis, improving life quality.
Incremental HaemodialysisFrance - Not yet recruiting
Association Between Composition of the Gut Microbiota and Nutritional Status in Digestive Oncology
This study looks at how the tiny bugs in your gut and mouth might affect nutrition in people with digestive cancer. It hopes to find better ways to help patients stay well-nourished during chemotherapy by understanding these microbes.
Digestive CancerFrance - RecruitingPHASE2, PHASE3
A Study of Zilovertamab Vedotin (MK-2140) in Combination With Standard of Care in Participants With Relapsed or Refractory Diffuse Large B-Cell Lymphoma (rrDLBCL) (MK-2140-003)
This study is testing a new medicine, zilovertamab vedotin (ZV), combined with standard treatments for a type of lymphoma called diffuse large B-cell lymphoma (DLBCL). It's for people whose lymphoma has come back or hasn't responded to previous treatments.
DLBCLDiffuse Large B-Cell LymphomaFrance - RecruitingNA
Endoscopic Sutured Gastroplasty with Endomina® Device Versus Standard of Care in Patients with Type 2 Diabetes and Class I Obesity: a Multi-center, Randomized Controlled Trial
This study looks at a new stomach-reduction procedure for people with type 2 diabetes and obesity. It compares this procedure, called endoscopic gastroplasty using the Endomina device, with standard care to see if it helps put diabetes into remission.
Diabetes Mellitus, Type 2ObesityFrance - Recruiting
PACOME (PAtient Cancer Oral MEdication) Cohort of Patients Treated With Oral Anticancer Drugs Benefiting From Oncoral Multidisciplinary Monitoring in Real Life: Predictive Factors and Safety of Treatments
This study looks at how people with cancer taking oral medications at home are supported through a special programme called Oncoral. It aims to understand how well these treatments work in real life and how to make care better for patients outside of the hospital.
CancerOncologyOncoral ProgramFrance - AuthorisedTherapeutic exploratory (Phase II)
A Phase 2 Study to Evaluate the Safety and Efficacy of Telisotuzumab Adizutecan for the Treatment of Subjects with Locally Advanced or Metastatic Solid Tumors that Harbor MET Amplification
This study is looking at a new drug, Telisotuzumab Adizutecan, for people with advanced solid cancers that have a specific genetic change called 'MET amplification'. Researchers want to see how safe and effective this drug is at shrinking these cancers.
Locally Advanced or Metastatic Solid Tumours that harbour MET Amplification geneFrance - RecruitingPHASE3
A Study of Sepiapterin in Participants With Phenylketonuria (PKU)
This study is looking at a new medicine called sepiapterin for children with Phenylketonuria (PKU). It aims to see if starting this medicine early can help protect their brain development over a long time.
PhenylketonuriaFrance - Active not recruitingPHASE3
Study of Talazoparib With Enzalutamide in Men With DDR Gene Mutated mCSPC
This study is for men with a certain type of advanced prostate cancer (mCSPC) that has spread and has specific gene changes. It compares a new drug called talazoparib, given with standard treatment enzalutamide, against enzalutamide alone, to see if it's safe and effective.
Prostate CancerFrance - Active not recruitingPHASE3
A Study to Compare the Efficacy and Safety of Luspatercept (ACE-536) Versus Epoetin Alfa for the Treatment of Anemia Due to IPSS-R Very Low, Low, or Intermediate Risk Myelodysplastic Syndromes (MDS) Participants Who Require Red Blood Cell Transfusions and Are ESA Naïve
This study compares a new medicine, luspatercept, with a standard one, epoetin alfa, for people with a type of blood disorder called myelodysplastic syndromes (MDS). It aims to see if luspatercept can reduce the need for blood transfusions.
Myelodysplastic SyndromesFrance - RecruitingPHASE2, PHASE3
FORTIFI-HN01: A Study of Ficerafusp Alfa (BCA101) or Placebo in Combination With Pembrolizumab in First-Line PD-L1-pos, R or M HNSCC
This study looks at a new drug, ficerafusp alfa, combined with pembrolizumab (Keytruda®) for people with advanced head and neck cancer. It compares this combination against pembrolizumab alone to see if it works better and is safe.
Metastatic Head and Neck Squamous Cell CarcinomaRecurrent Head and Neck Squamous Cell CarcinomaFrance - RecruitingPHASE3
A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)
This study looks at a new drug called anifrolumab for adults with muscle conditions like polymyositis or dermatomyositis. Researchers want to see if it's safe and helps improve symptoms when added to their usual treatment.
Polymyositis, DermatomyositisFrance - Active not recruiting
Real World Data Collection in Subjects Treated With the FARAPULSE Pulsed Field Ablation System
This study looks at how safe and effective a new treatment called FARAPULSE is for atrial fibrillation. It collects real-world information about people treated with this system in hospitals to see how well it works and if it improves their quality of life.
Atrial FibrillationFrance - RecruitingNA
Assessment of the Impact of Oral Health Training for Caregivers on the Oral Health-related Quality of Life of Residents in Nursing Homes
This study looks at how training care home staff in oral health can improve residents' quality of life. Many older people in care homes have poor mouth health, and this study aims to see if better training for staff can make a difference.
Oral Health TrainingFrance - Recruiting
B Cell Functions in Periodontitis
This study looks at special immune cells, called B cells, in people with gum disease (periodontitis). Researchers want to understand how these cells act in the blood and gums to help find better ways to diagnose and treat this condition.
Chronic PeriodontitisAggressive PeriodontitisFrance - RecruitingPHASE2
A Study to Learn More About the Study Medicine Called Inotuzumab Ozogamicin (InO) in Children (1 to <18 Years) With First Relapse ALL
This study looks at a new medicine, Inotuzumab Ozogamicin (InO), for children aged 1 to 17 with a type of blood cancer called Acute Lymphoblastic Leukaemia (ALL) that has come back. It compares InO to a standard treatment to see which works better and is safer.
ACUTE LYMPHOBLASTIC LEUKEMIAFrance - Recruiting
Rhizarthrosis Surgery and Functional Recovery: Arthroplasty vs. Trapezectomy
This study compares two common surgeries for thumb joint arthritis (rhizarthrosis) to see which works best. It looks at a whole new joint replacement versus removing a small bone in the thumb. The aim is to find out which surgery helps people recover better and quicker.
RhizarthrosisFrance - Active not recruitingNA
ASCEND CSP IDE Study
This study is testing a new type of heart device lead for people with heart failure. It looks at how safe and effective the "CSP ICD Lead" is when used with special heart devices to help control irregular heartbeats and improve heart function.
Heart FailureVentricular ArrythmiaFrance - Active not recruitingPHASE3
Phase 3 Study of Daraxonrasib (RMC-6236) in Patients With Previously Treated Metastatic Pancreatic Ductal Adenocarcinoma (PDAC)
This study is looking for a new treatment for pancreatic cancer that has spread. It compares a new medicine called RMC-6236 with standard chemotherapy for people whose cancer has already been treated once before. The aim is to see if the new medicine is safer and works better.
Pancreatic CancerPDACPDAC - Pancreatic Ductal AdenocarcinomaFrance - Active not recruitingPHASE3
Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC
This study looks at a new way to treat muscle-invasive bladder cancer using a drug called Durvalumab alongside standard chemotherapy. It aims to see if this combination, given before and after surgery, can improve treatment outcomes and safety for patients.
Muscle Invasive Bladder CancerFrance - RecruitingPHASE1
A Study of CLN-978, a Subcutaneously Administered CD19-directed T Cell Engager, in Subjects With Sjogren's Disease
This study is looking at a new medicine called CLN-978 for people with Sjögren's disease. It's an early-stage study to see how safe it is and how well it works. The medicine is given as an injection under the skin.
SjögrenSjogren DiseaseSjogren's SyndromeFrance - Active not recruitingPHASE3
Phase 3, Multicenter, Randomized Study, Evaluating the Efficacy and Tolerability of Focused HIFU (High Intensity Focused Ultrasound) Therapy Compared to Active Surveillance in Patients With Significant Low Risk Prostate Cancer
This study is looking at a new way to treat early-stage prostate cancer called HIFU. It compares this focused ultrasound treatment to simply watching the cancer closely. We want to see if HIFU can destroy the cancer without the severe side effects of traditional surgery, offering a kinder treatment option.
Prostate CancerFrance - RecruitingPHASE3
Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).
This study looks at the long-term safety of a new medicine, ianalumab, for people with lupus. It's for those who have already been in an earlier ianalumab study and continues to check how safe and well the medicine is tolerated over time.
Systemic Lupus ErythematosusFrance - RecruitingNA
Closed-loop in Adults With Type 2 Diabetes
This study looks at a new 'artificial pancreas' system, CamAPS HX, for adults with type 2 diabetes who use insulin. It aims to see if this automated system can better control blood sugar at home compared to standard care, checking its safety and how easy it is to use.
Type 2 Diabetes Treated With InsulinFrance - RecruitingPHASE2, PHASE3
An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma
This study aims to improve treatment and understanding of childhood ependymoma. It involves different treatment approaches, including chemotherapy and radiotherapy, for children and young adults up to 22 years old. The goal is to find better ways to help these patients.
Childhood EpendymomaFrance - Active not recruitingNA
Pregnancy Outcome and Safety of Interrupting Therapy for Women With Endocrine Responsive Breast Cancer
This study aims to understand if temporarily stopping hormone therapy for early breast cancer to allow for pregnancy is safe. It will also look at fertility and emotional well-being for young women.
Early Breast CancerFrance - Active not recruitingPHASE2
A Study of the Efficacy and Safety of Adjuvant Autogene Cevumeran Plus Atezolizumab and mFOLFIRINOX Versus mFOLFIRINOX Alone in Participants With Resected PDAC
This study looks at new treatments for pancreatic cancer after surgery. It compares a new combination of drugs (Autogene Cevumeran, Atezolizumab, and mFOLFIRINOX) with a standard treatment (mFOLFIRINOX alone) to see which works best and is safest for patients with no remaining cancer after their operation.
Adenocarcinoma, Pancreatic DuctalFrance - Recruiting
Endoscopic Gastric Tubulization
This study looks at a keyhole procedure called endoscopic gastric tubulization for adults with very severe obesity. It aims to see how well patients lose weight, feel better, and how long the effects last, using a commonly used stitching device.
Morbid ObesityFrance - RecruitingNA
Telemonitoring Platform "CUREETY TECHCARE" vs Standard of Care for mTBNC Patients Initiating a First-line Treatment
This study looks at whether a digital health platform called CUREETY TECHCARE can improve the lives of people with a type of breast cancer called metastatic triple-negative breast cancer. It compares patients using the platform with those receiving standard care.
Metastatic Triple-Negative Breast CarcinomaFrance - Active not recruitingPHASE1, PHASE2
A Phase 1b/2 Study of T-DXd Combinations in HER2-positive Metastatic Breast Cancer
This study is looking at new combinations of medicines for HER2-positive breast cancer that has spread. It aims to see how safe and effective these combinations are in patients whose advanced breast cancer has come back or spread.
Metastatic Breast CancerFrance - Active not recruitingPHASE1
A Study of Safety and Efficacy of KFA115 Alone and in Combo With Pembrolizumab in Patients With Select Advanced Cancers
This study looks at a new drug, KFA115, on its own and with another drug, pembrolizumab, for various advanced cancers. It aims to find a safe and effective dose, helping doctors understand how these treatments work.
Carcinoma, Non-Small-Cell LungCutaneous MelanomaCarcinoma, Renal CellCarcinoma, Ovarian EpithelialFrance - RecruitingPHASE1
Study of ARO-ATXN2 Injection in Adults With Spinocerebellar Ataxia Type 2
This study is testing a new injection called ARO-ATXN2 for adults with Spinocerebellar Ataxia Type 2 (SCA2). It aims to see if the treatment is safe and how the body handles it. Participants will receive either the new drug or a dummy injection.
Spinocerebellar Ataxia Type 2France - Recruiting
Drug-Eluting Registry: Real-World Treatment of Lesions in the Peripheral Vasculature
This study looks at how well Boston Scientific's special drug-coated devices work in treating blood vessel problems in people's arms and legs. It helps doctors understand their real-world use for conditions like Peripheral Vascular Disease.
Peripheral Vascular DiseasesFrance - RecruitingPHASE3
A Phase 3 Study of Ersodetug in Patients With Tumor Hyperinsulinism
This study is testing a new drug, Ersodetug, for adults with a rare condition called Tumour Hyperinsulinism (Tumour HI). It aims to see if the drug can help control very low blood sugar levels caused by certain tumours, when current treatments aren't enough.
Tumor Hyperinsulinism (Tumor HI)France - Active not recruitingNA
Adjuvant Chemotherapy in Patients With Intermediate or High Risk Stage I or Stage IIA Non-squamous Non-Small Cell Lung Cancer: AIM-HIGH (Adjuvant Intervention in Molecular High Risk Patients)
This study looks into whether extra chemotherapy after surgery helps people with early-stage non-small cell lung cancer that is considered high risk. It uses a special gene test to identify these patients and compares two ways of looking after them.
Non-Small Cell Lung CancerFrance - AuthorisedPhase II and Phase III (Integrated)
A Phase 2/3 randomized, open-label study of MK-1045 in combination with rituximab in patients with 1L follicular lymphoma.
This study is looking at a new drug called MK-1045, combined with a standard treatment (rituximab), for people newly diagnosed with a type of cancer called follicular lymphoma. Researchers want to see if this new combination is safe and effective in slowing down or stopping the cancer's growth.
Follicular LymphomaFrance - Enrolling by invitationPHASE2, PHASE3
HELIOS: Open-Label, Long-Term Extension Study to Investigate the Safety, Tolerability, and Efficacy of DISC-1459 (Bitopertin) in Participants With EPP or XLP
This study looks at a new medicine called DISC-1459 (Bitopertin) for people with Erythropoietic Protoporphyria (EPP). It's an ongoing study to see if the medicine is safe, well-tolerated, and effective over a long time for those who have already tried it in earlier studies.
Erythropoietic ProtoporphyriaFrance - Active not recruitingPHASE1, PHASE2
A Phase 1/2, Study Evaluating the Safety, Tolerability, PK, and Efficacy of Sotorasib (AMG 510) in Subjects With Solid Tumors With a Specific KRAS Mutation (CodeBreaK 100)
This study is testing a new medicine called sotorasib for people with specific advanced cancers carrying a KRAS p.G12C gene change. Researchers want to see if it's safe, how much to give, and if it helps shrink tumours. It's an early-stage trial looking for better cancer treatments.
KRAS p.G12C Mutant Advanced Solid TumorsFrance - RecruitingPHASE2
A Study of IPN10200 for the Treatment of Cervical Dystonia in Adults
This study is testing a new drug, IPN10200, for adults with cervical dystonia. It aims to see if IPN10200 is safe and works better than a dummy drug (placebo) to reduce neck pain and stiffness, with potentially longer-lasting effects than current treatments.
Cervical DystoniaFrance - Active not recruitingPHASE2
A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC)
This study is testing a new medicine, volixibat, for people with Primary Sclerosing Cholangitis (PSC) who experience bothersome itching. It aims to see if the medicine can reduce itching and affect how PSC progresses.
Primary Sclerosing CholangitisFrance - Active not recruitingPHASE1
Anvumetostat Alone or in Combination With Other Therapies in Subjects With Advanced Thoracic Tumors With Homozygous MTAP-deletion (Master Protocol) (MTAPESTRY 104).
This study, called MTAPESTRY 104, is testing a new drug called Anvumetostat, alone or with other treatments, for advanced lung cancers that have a specific genetic change (MTAP-deletion). It aims to find the safest and most effective dose.
Thoracic TumorsNon-small Cell Lung CancerFrance - Active not recruitingPHASE1, PHASE2
A Study Evaluating the Efficacy and Safety of Cevostamab in Prior B Cell Maturation Antigen (BCMA)-Exposed Participants With Relapsed/Refractory Multiple Myeloma
This study looks at a new medicine called cevostamab for people with multiple myeloma that has come back or isn't responding to treatment. It checks how well it works and if it's safe when given through a drip.
Multiple MyelomaFrance - RecruitingNA
Impulsivity With Borderline Personality Disorder/tMS
This study is looking into a new brain stimulation treatment for people with Borderline Personality Disorder (BPD) to help reduce impulsivity. It compares two types of this stimulation to see if one is more effective.
Borderline Personality DisorderFrance - Active not recruitingPHASE1
DAREON™-7: A Study to Test How Well Different Doses of BI 764532 in Addition to Chemotherapy Are Tolerated by People With Advanced Neuroendocrine Cancers
This study looks at a new medicine, BI 764532, combined with chemotherapy for advanced neuroendocrine cancers. It aims to find safe doses and see if it helps patients whose cancers have a specific marker called DLL3.
Neuroendocrine NeoplasmsFrance