Latest studies
- Recruiting
SMILE: Supporting mental health in young people: integrated methodology for clinical decisions and evidence-based interventions
The SMILE study helps young people (10-24) with anxiety or depression. It uses a fun online game and activities to build resilience and improve mental health. The study runs from February 2025 to July 2026 across seven countries, including the UK.
Depression and anxiety in children and young peopleUnited Kingdom - Active not recruitingPHASE3
A Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Fenfluramine (Hydrochloride) in Infants 1 Year to Less Than 2 Years of Age With Dravet Syndrome
This study is looking at a medicine called fenfluramine in very young children (aged 1 to just under 2 years old) with a rare type of epilepsy called Dravet syndrome. It aims to check if the medicine is safe and well-tolerated at different doses.
Dravet SyndromeUnited Kingdom - Completed
Breast cancer risk reduction through family-based lifestyle change
This study looks at a 12-week family-focused healthy lifestyle programme for mothers in Manchester. It aims to help women at higher risk of breast cancer lose weight and make healthier choices to see if this type of programme works well for families.
Prevention of breast cancer in women at increased riskUnited Kingdom - CompletedPhase III
A study to assess the safety of using 100 mg methotrexate for the treatment of an unruptured ectopic pregnancy
This study aims to see if a standard 100mg dose of methotrexate is safe and effective for women with a stable ectopic pregnancy. This could help make treatment quicker and simpler, avoiding individual dose calculations and long waiting times.
Ectopic pregnancyUnited Kingdom - RecruitingPhase II
Role of at-home treatment of heart failure and kidney disease patients with under-the-skin injection of "furosemide" for fluid removal
This study looks at treating fluid build-up in heart and kidney disease patients at home using a special medicine pump. It aims to see if this can stop people from needing to go to hospital, which can be an unpleasant experience.
Heart failure with chronic kidney disease, with fluid overloadUnited Kingdom - Recruiting
Artificial intelligence to help healthcare professionals detect cancer in the UK breast screening programme
This study looks at how artificial intelligence (AI) can help find breast cancer in mammograms. It compares AI working with human experts to human experts working alone, hoping to improve breast screening for women across the UK.
Breast cancerUnited Kingdom - RecruitingPHASE3
A Study to Learn About the Study Medicine Elranatamab Alone and With Daratumumab in People With Multiple Myeloma Who Have Received Other Treatments
This study looks at new ways to treat multiple myeloma. Researchers are testing a drug called elranatamab, alone and with daratumumab, against a standard treatment. The aim is to find better and safer treatments for people who have tried other medicines.
Multiple MyelomaUnited Kingdom - Active not recruiting
Spasmodic Dysphonia Interviews
This study wants to talk to people with Spasmodic Dysphonia, a voice condition, to understand how it affects their daily lives, work, and social activities. Researchers will ask about their experiences, including how botulinum toxin injections help them.
Spasmodic DysphoniaQuality of LifeUnited Kingdom - Active not recruitingPHASE2, PHASE3
International Society of Paediatric Oncology (SIOP) PNET 5 Medulloblastoma
This study looks at new ways to treat medulloblastoma, a type of brain tumour, in children and young people. It aims to find the best treatments based on the tumour's specific characteristics, hoping to improve the chances of recovery with fewer side effects.
Brain TumorsUnited Kingdom - Active not recruitingPHASE2
An Extension Study to Evaluate the Long-Term Safety and Efficacy of Votoplam in Participants With Huntington's Disease (HD)
This study is looking into the long-term safety and effects of a medicine called Votoplam for people with Huntington's disease. Participants who were already in a previous study with Votoplam will continue to take it to see how it works over a longer time.
Huntington DiseaseUnited Kingdom - Completed
Imaging lithium in Alzheimer's disease
This study looks at how a drug called lithium goes into the brain in people with Alzheimer's and healthy volunteers. Researchers want to see if a special MRI scan can detect lithium in the brain and how different doses affect it. This could help develop new treatments for Alzheimer's.
Specialty: Dementia and Neurodegeneration, Primary sub-specialty: Dementia; Health Category: Neurological; Disease/Condition: Other degenerative diseases of the nervous systemUnited Kingdom - Completed
Understanding corridor care in UK emergency departments
This study looks at how many patients are cared for in places like hospital corridors when emergency departments are busy. It wants to understand who these patients are and why they're there, to help improve emergency care across the UK.
UK Emergency Department use of escalation areasUnited Kingdom - Recruiting
Adapting ENGAGE-PD physical activity coaching for individuals newly diagnosed with Parkinson’s: perspectives of healthcare professionals using Nominal Group Technique consensus
This study asks NHS staff who help people with Parkinson's for their ideas. They want to create a UK version of a programme called ENGAGE-PD. This programme helps people with newly diagnosed Parkinson's be more physically active, which can be very beneficial for their condition.
Perspectives of UK National Health Service (NHS) staff working in neurology and/or healthcare of the elderly services providing NHS physiotherapy rehabilitation services for people with Parkinson's.United Kingdom - Recruiting
Understanding how COPD flare-ups change the body's recovery process
This study looks at how COPD flare-ups affect your body's recovery. Researchers want to understand why people don't fully recover and how frequent flare-ups worsen health, so they can find better ways to help.
Chronic obstructive pulmonary disease (COPD)United Kingdom - RecruitingPhase I
Safety and performance of OsStic synthetic injectable structural bio adhesive bone void filler in a first in human application to treat tibial fractures
This study is testing a new injectable material called OsStic for shin bone fractures. It aims to see if OsStic is safe and helps broken shin bones heal by filling gaps, potentially improving recovery for patients. It's for adults with specific shin bone breaks.
Tibial plateau fracturesUnited Kingdom - Recruiting
Cash for families
This study looks at whether giving money to families involved with social services can help improve children's mental health and wellbeing. Families either get extra financial support or continue with usual services. Researchers want to see if this helps reduce stress and improve home life.
Mental health and wellbeing of children with social care input (i.e. Child in Need (CiN) or Child Protection Plan (CPP) status)United Kingdom - Recruiting
Exploring food choice across the menstrual cycle
This study looks at how food choices might change during the menstrual cycle for women who experience heavy periods. It involves answering questions online and doing a few simple finger-prick blood tests from home.
Individuals who report their menstrual bleeding to meet the criteria specified for heavy menstrual bleeding.United Kingdom - Not yet recruitingPhase II
Comparing a new combination of medicines to the usual intensive chemotherapy treatment given to participants who have been recently diagnosed with acute myeloid leukaemia
This study compares a new four-drug treatment to standard chemotherapy for adults with a type of blood cancer called Acute Myeloid Leukaemia (AML). It aims to find better ways to help more patients receive a life-saving transplant.
Newly diagnosed Acute Myeloid LeukaemiaUnited Kingdom - CompletedPhase I
An experimental study to assess a diphenylcyclopropenone skin challenge model in healthy participants for the evaluation of immunomodulatory therapies
This study tests a mild skin irritation method to understand how the immune system works. We're looking for healthy adults, aged 18-55, to participate. The goal is to find new ways to test medicines for conditions like autoimmune diseases and cancer without always needing sick patients.
Diphenylcyclopropenone skin challenge models are studied in healthy participants for the evaluation of immunomodulatory therapiesUnited Kingdom - RecruitingNot Applicable
A trial investigating the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) for misophonia
This study explores if a gentle electrical device, called tVNS, can help people with misophonia. Misophonia is when certain sounds cause strong negative reactions like anger or anxiety. Participants will use the device at home for four weeks, have MRI scans, and complete questionnaires.
MisophoniaUnited Kingdom - Not yet recruiting
Musculoskeletal conditions in underserved communities
This study looks into common pain conditions like arthritis in communities that are often overlooked. Researchers want to understand why more people in these areas suffer from pain and how to better help them. It involves surveys and interviews to gather important information and improve healthcare.
MusculoskeletalUnited Kingdom - Recruiting
A Study to Evaluate Patient-Reported Satisfaction, Effectiveness, and Safety of Atezolizumab in Participants Treated in Routine Clinical Practice
This study looks at how well a medicine called Atezolizumab works and how happy people are with it when used for lung cancer or a type of liver cancer in normal NHS care. It also checks for side effects.
Lung Cancer, Hepatocellular CarcinomaUnited Kingdom - Recruiting
Supported inspiratory muscle training for people with chronic obstructive pulmonary disease who have declined pulmonary rehabilitation
This study looks at a new way to help people with COPD who haven't joined breathing exercise programmes. It tests if supported breathing muscle training can improve symptoms and help prepare them for future rehabilitation. We're also checking how well our study design works for a bigger trial later.
Chronic obstructive pulmonary diseaseUnited Kingdom - Recruiting
Using an NHS walking app to support physical activity in older adults during NHS health-checks: a feasibility study
This study looks at whether an NHS walking app helps people over 55 who don't move much to become more active. Half the people will use the app and the other half get an exercise leaflet. It's a small study to prepare for a larger one.
Prevention of physical inactivity among older adultsUnited Kingdom - Completed
Standardisation, acceptability and outcomes of elective (planned) caesarean births where the baby's head is delivered first, and the baby is not fully delivered until after they have taken their first cry or 2 minutes have passed (whichever is sooner)
This study looks at a new way to do planned C-sections where the baby's head is delivered first, then there's a short wait before the rest of the baby is born. This might help babies breathe easier after birth by giving them time to clear fluid from their lungs.
Planned (elective) caesarean sectionUnited Kingdom - Recruiting
A study to compare a single drainage procedure (therapeutic aspiration) versus a standard chest tube for the initial treatment of infected fluid around the lung
This study compares two ways to drain infected fluid from around the lung: a standard chest tube or a single, less invasive drainage. It also looks at how antibiotics work. The goal is to help patients get better faster and go home sooner.
Management of pleural infectionUnited Kingdom - RecruitingPhase III
IIH-Advance: A randomised clinical trial to determine the effects of weight loss, induced by a weight loss drug (Tirzepatide), in adults with active idiopathic intracranial hypertension
This study looks at whether a weight loss drug, Tirzepatide, can help adults with a condition called Idiopathic Intracranial Hypertension (IIH). IIH causes high pressure in the head, leading to headaches and eye problems. We want to see if losing weight with this drug can improve these symptoms.
Idiopathic intracranial hypertensionUnited Kingdom - Recruiting
The Epithelioid Hemangioendothelioma Registry of the European Reference Network on Rare Adult Solid Cancers (EURACAN)
This registry tracks new adult cases of a rare cancer called Epithelioid Hemangioendothelioma (EHE). It aims to better understand the disease, its progression, and how different treatments work, by collecting information from patients across Europe and the UK.
Epithelioid HemangioendotheliomaSarcoma,Soft TissueUnited Kingdom - Recruiting
Exploring the public's opinion on the use of their data in biobanking, linked to routine medical records, and the use of artificial intelligence in care and medical research
This study wants to hear your thoughts on how your health information and samples are used in research. This includes stored samples, health records, and new computer programs called AI. We want to know what you think about how these are used to improve healthcare, especially for long-term health problems.
Mainly focused on but not exclusive to chronic inflammatory conditions: GI (inflammatory bowel disease), musculoskeletal (inflammatory arthritis such as rheumatoid arthritis, ankylosing spondylitis), skin (psoriasis, eczema, hydradenitis), and liver (autoimmune hepatitis, primary sclerosing cholangitis, primary biliary cirrhosis).United Kingdom - RecruitingPhase I
A phase 1 trial in healthy adults and adults with increased inherited risk of developing blood clots
This study is testing a new medicine, CITY-FXI, for the very first time in people. It aims to prevent dangerous blood clots with less risk of bleeding than current treatments. We're looking for healthy adults and those with a higher risk of clots to help us learn about its safety and effects.
Factor V Leiden or prothrombin G20210A mutation in healthy adults and adultsUnited Kingdom - Completed
Understanding how people shop for soft drinks and alcoholic beverages in grocery stores; understanding drinking experiences at home
This study looks at how calorie labels on alcoholic drinks might change what UK adults buy and drink. Participants will do a pretend shopping trip and track their drinking at home for two weeks. It aims to see if labels help reduce alcohol consumption.
Excessive alcohol consumption in UK adultsUnited Kingdom - Recruiting
A study to test whether a new website, Sleep Buddy, developed by doctors and psychologists, can help parents and carers of children aged 6-12 years with a diagnosis of ADHD who are experiencing sleep problems to improve their child’s sleep
This study looks at whether a new website called Sleep Buddy can help parents of children aged 6-12 with ADHD improve their child's sleep. Many children with ADHD struggle with sleep, which can affect their daily lives. The website offers advice and tips.
Insomnia and ADHD (attention deficit hyperactivity disorder)United Kingdom - Recruiting
Respiratory Health and Wellbeing Post Pulmonary Tuberculosis
This study looks at how people in the UK feel and breathe after being treated for tuberculosis (TB). We want to understand if TB leaves lasting lung problems, even after treatment, to help improve future care for everyone affected.
Tuberculosis (TB)United Kingdom - Recruiting
A clinical trial to find out if using the findings from PSMA PET scans to escalate treatment can improve cancer control in patients with high-risk prostate cancer
This study looks at new scans (PSMA PET-CT) for men with high-risk prostate cancer. We want to see if using these scans to guide treatment can help control the cancer better than standard scans. It could improve future care for prostate cancer patients.
Prostate cancerUnited Kingdom - CompletedPhase I
A study of Pasritamig (JNJ-78278343) in combination with JNJ-86974680 for treatment of prostate cancer
This study is testing two new drugs, Pasritamig and JNJ-86974680, together for men with advanced prostate cancer. Researchers want to find the safest dose and see if it helps fight the cancer. It's a very early-stage trial.
Prostate cancerUnited Kingdom - Recruiting
Barts Revascularisation Registry
This study looks at heart disease (myocardial infarction and angina) and how different treatments, like procedures to open blocked arteries, affect patients. It uses existing information from a large heart centre to learn more about these conditions and improve care.
Myocardial InfarctionStable AnginaUnited Kingdom - Recruiting
A study of Sensore: continuous pressure monitoring for wheelchair users
This study looks at how easy and useful a system called Sensore is for wheelchair users. Sensore helps show when pressure builds up, so people know when to change position. Researchers want to see if people can use it in their daily lives to help manage pressure ulcers.
Usability and acceptability of a continuous pressure monitoring system for pressure ulcer risk management in adult wheelchair users and their carers and healthcare professionals.United Kingdom - RecruitingPhase II
A study to test if LACTIN-V, a type of probiotic made from a specific bacteria (Lactobacillus crispatus CTV-05), is safe and effective in lowering the chances of preterm labour in women who are considered at high risk for giving birth early
This study looks at whether a probiotic called LACTIN-V can help reduce the chance of giving birth too early (preterm labour) in women who are at high risk. It tests if it's safe and if it works to keep babies from being born prematurely.
Preterm labourUnited Kingdom - Active not recruiting
Study Evaluating LDL-C Change and Adherence to Inclisiran Lipid-lowering Therapy in ASCVD
This study looks at how well a medicine called inclisiran works for people with high cholesterol and helps prevent heart problems. We want to see if it lowers bad cholesterol and if people stick to taking it as part of their usual care.
Primary HypercholesterolemiaMixed DyslipidemiaUnited Kingdom - Active not recruitingNA
Trial on Radical Upfront Surgery in Advanced Ovarian Cancer
This study looks at the best time to have surgery for advanced ovarian cancer. It compares having surgery first, then chemotherapy, versus having some chemotherapy first, then surgery, then more chemotherapy, to see which approach works better.
Ovarian CancerUnited Kingdom - Active not recruitingPHASE2, PHASE3
A Study to Investigate the Efficacy and Safety of Efgartigimod PH20 SC in Adult Participants With Active Idiopathic Inflammatory Myopathy.
This study looks at a new drug, efgartigimod PH20 SC, for adults with active idiopathic inflammatory myopathy (IIM), a condition causing muscle weakness and inflammation. It compares the drug to a dummy treatment to see if it helps improve muscle strength and overall well-being.
Active Idiopathic Inflammatory MyopathyMyositisDermatomyositisPolymyositisUnited Kingdom - Recruiting
The role and impact of same day emergency care
This study looks at how new Same Day Emergency Care (SDEC) services are helping hospitals. Many A&E departments are busy, and SDEC aims to treat patients quickly without them staying overnight. Researchers want to see if SDEC is working well for patients and saving hospital resources.
Emergency careUnited Kingdom - RecruitingPhase III
Investigating whether prolonged antibiotics can prevent permanent Pseudomonas infection in bronchiectasis
This study looks at whether early, strong antibiotic treatment can stop a lung infection called Pseudomonas from becoming permanent in people with bronchiectasis. We hope to reduce flare-ups and improve health.
BronchiectasisUnited Kingdom - Active not recruitingNA
Shoulder Surgery Traditional vs Accelerated Rehabilitation Trial
This study compares two ways to recover after shoulder surgery for a torn tendon. One involves using a sling for 6 weeks, and the other doesn't. Researchers want to see which leads to better results for patients.
Rotator Cuff TearRotator Cuff Tear or Rupture, Not Specified as TraumaticUnited Kingdom - Recruiting
Improving diversity in clinical research for patients undergoing surgery (PROTECT-DIVERSITY)
This study aims to make sure more people can take part in medical research, especially those having surgery. We're looking at how different consent forms and ways of collecting information can help include a wider range of patients in studies.
Adult patients undergoing elective surgeryUnited Kingdom - Recruiting
Use of facial monitoring technology for recording vital signs in the emergency department waiting room: a feasibility study
This study looks at whether patients can use their smartphones to check their own vital signs (like heart rate and breathing) in the emergency department waiting room. It also checks if staff and patients think this is a good idea. This could help make care quicker and easier.
Adult walk-in patients in the Emergency Department (ED) and ED staffUnited Kingdom - RecruitingNA
Structured Review: To Optimise Management and Prevent Harm in COPD
This study aims to help people with COPD who have frequent flare-ups. We want to improve their treatment, check for other health problems, and reduce how often they need steroid tablets, which have side effects. It’s a thorough health check to help you feel better.
COPDUnited Kingdom - CompletedPhase I
A Phase I trial of LY3143921 hydrate in solid tumours
This study looks at a new drug, LY3143921 hydrate, for advanced solid cancers. It aims to find a safe dose and understand its effects, especially in cancers where usual treatments haven't worked or aren't suitable. This is the first time it’s being tested in people.
Colorectal Cancer (CRC), High Grade Serous Ovarian Cancer (HGSOC), Non-Small Cell Lung Cancer (NSCLC; Squamous Cell Variant), Squamous Carcinoma of the Oesophagus, Squamous Carcinoma of the Head and Neck (Human Papillomavirus Negative), Urothelial Cancer, Breast Cancer (Triple Negative Type), Pancreatic CancerUnited Kingdom - Recruiting
Carbon monoxide screening in ED patients with headache
This study looks at how often carbon monoxide (CO) exposure causes headaches in people visiting the emergency department. It uses simple tests, including a finger sensor and a home monitor, to see if CO could be the cause and help doctors recognise it sooner.
Carbon monoxide screening in ED patients with headacheUnited Kingdom - Recruiting
Reducing blood clots in donated livers before transplantation
This study looks at whether a special treatment for donor livers can prevent problems after a liver transplant. We're testing if giving a 'clot-buster' medicine to the liver before transplant helps prevent scarring in the bile ducts, which can cause serious problems.
Liver transplantationUnited Kingdom