Juvenile primary osteoporosis
Last updated 18 Aug 2020
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Juvenile primary osteoporosis is a skeletal disorder characterised by thinning of the bones (osteoporosis) that begins in childhood. Osteoporosis is caused by a shortage of calcium and other minerals in bones (decreased bone mineral density), which makes the bones brittle and prone to fracture. Affected individuals often have multiple fractures in the long bones of the arms and legs, especially in the regions where new bone forms (metaphyses). They also have fractures in the bones that form the spine (vertebrae), which can cause collapse of the affected vertebrae (compressed vertebrae). Multiple fractures can cause bone pain and lead to movement problems.
Description
Juvenile primary osteoporosis is a skeletal disorder characterised by thinning of the bones (osteoporosis) that begins in childhood. Osteoporosis is caused by a shortage of calcium and other minerals in bones (decreased bone mineral density), which makes the bones brittle and prone to fracture. Affected individuals often have multiple fractures in the long bones of the arms and legs, especially in the regions where new bone forms (metaphyses). They also have fractures in the bones that form the spine (vertebrae), which can cause collapse of the affected vertebrae (compressed vertebrae). Multiple fractures can cause bone pain and lead to movement problems.
Inheritance patterns
The source lists the following possible inheritance patterns: Autosomal dominant. More than one pattern can apply in different cases.
Related genes
Other names
Childhood-onset primary osteoporosis
Idiopathic juvenile osteoporosis
Related patient information and medicines
Patient information leaflet
Juvenile idiopathic arthritis
Juvenile idiopathic arthritis is a condition in which persisting joint inflammation first occurs in children under the age of 16 years. Affected joints become painful and swollen, and can become damaged. So, juvenile idiopathic arthritis (JIA) is a condition in which this inflammation of one or more joints begins in children under the age of 16.
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Joint pain
Paget's disease of bone : see the separate leaflet called Paget's disease o... Causes of joint pain in children and adolescents Many of the causes of joint pain in adults can also be the cause in children. However, because of developing bones and joints, there are other conditions that can cause joint pain in children and teenagers. These include:.
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Rheumatoid arthritis
Arthritis means inflammation of joints. Rheumatoid arthritis (RA) is a fairly common form of arthritis. (There are various other causes of arthritis and RA is just one cause.). It can develop at any age, but most commonly starts between the ages of 30 and 50. It can occur in children and teenagers but this is very rare. See the separate leaflet.
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Vitamin D deficiency
Vitamin D deficiency happens when your body does not have enough vitamin D. This is a nutrient that helps keep bones, teeth, and muscles healthy. Low levels can weaken your bones and increase the risk of osteoporosis and bone fractures. Slow wound healing. Bone loss (osteoporosis) with long-term deficiency. Some people with vitamin D deficiency.
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Arthritis
Arthritis means inflammation in a joint (like your knee, hip, elbow or fingers). It is a common problem and generally affects older people, although there are some rare conditions that cause arthritis in children and teenagers. There is a rare 'triad' syndrome where arthritis, urethritis and conjunctivitis ... Juvenile idiopathic arthritis.
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Thoracic back pain
Thoracic back pain is pain that occurs in the thoracic spine. The thoracic spine is located at the back of the chest (the thorax), mostly between the shoulder blades. Surveys to find out how many people have ... Evidence from studies suggest that between 15 and 35 in 100 people report having had thoracic back pain at some time. It appears to be as.
Further reading and references
- Juvenile primary osteoporosis; MedlinePlus, National Library of Medicine.
- Hartikka H, Makitie O, Mannikko M, Doria AS, Daneman A, Cole WG, Ala-Kokko L, Sochett EB. Heterozygous mutations in the LDL receptor-related protein 5 (LRP5) gene are associated with primary osteoporosis in children. J Bone Miner Res. 2005 May;20(5):783-9. doi: 10.1359/JBMR.050101. Epub 2005 Jan 4.
- Korvala J, Juppner H, Makitie O, Sochett E, Schnabel D, Mora S, Bartels CF, Warman ML, Deraska D, Cole WG, Hartikka H, Ala-Kokko L, Mannikko M. Mutations in LRP5 cause primary osteoporosis without features of OI by reducing Wnt signaling activity. BMC Med Genet. 2012 Apr 10;13:26. doi: 10.1186/1471-2350-13-26.
- Rauch F, Travers R, Norman ME, Taylor A, Parfitt AM, Glorieux FH. The bone formation defect in idiopathic juvenile osteoporosis is surface-specific. Bone. 2002 Jul;31(1):85-9. doi: 10.1016/s8756-3282(02)00814-1.
- Zhang C, Liu Z, Klein GL. Overview of pediatric bone problems and related osteoporosis. J Musculoskelet Neuronal Interact. 2012 Sep;12(3):174-82.
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