RUNX1 partner transcriptional co-repressor 1
Last updated 5 Jul 2022
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
The RUNX1T1 gene provides instructions for making a protein commonly referred to as ETO, which helps regulate the activity of genes. ETO is considered a transcriptional corepressor because it turns off (represses) gene activity. It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. It also interacts with other corepressors to help keep genes turned off.
Normal function
The RUNX1T1 gene provides instructions for making a protein commonly referred to as ETO, which helps regulate the activity of genes. ETO is considered a transcriptional corepressor because it turns off (represses) gene activity. It performs this function by attaching (binding) to proteins that normally turn genes on and blocking their activity. It also interacts with other corepressors to help keep genes turned off.
Conditions referring to this gene or chromosome
Other names
acute myelogenous leukemia 1 translocation 1, cyclin-D related
AML1T1
CBFA2T1
CDR
core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related
eight twenty one protein
ETO
MTG8
MTG8_HUMAN
myeloid translocation gene on 8q22
protein CBFA2T1
runt related transcription factor 1; translocated to, 1 (cyclin D related)
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
zinc finger MYND domain-containing protein 2
ZMYND2
Related patient information and medicines
Patient information leaflet
Can I take Citalopram and Co-codamol together?
Taking these two medicines together can increase the risk of a rare but serious condition called serotonin syndrome. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Disclaimer This information is for general educational purposes only and should not.
Patient information leaflet
Can I take Co-codamol and Mirtazapine together?
Co-codamol contains codeine (an opioid) and mirtazapine is an antidepressant; both have sedative effects. Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Disclaimer This information is for general educational purposes only and should not be relied.
Patient information leaflet
Can I take Co-amoxiclav and Ramipril together?
Taking co-amoxiclav and ramipril together can occasionally increase the risk of a rare but serious allergic reaction called angioedema (swelling under the skin). Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Disclaimer This information is for.
Patient information leaflet
Contraception methods
However, no method is completely (100%) reliable. The reliability for each method is given in percentages, or in numbers of women per 100 women. If the method fails in less than 1 in 100 women, the number of women who fall pregnant may be given per 1,000 women. For example, the contraceptive injection is more than 99% effective. In other words it.
Patient information leaflet
Common postoperative complications
Postoperative complications are problems which arise as a result of you having had surgery, which were not an intentional effect of the surgery. What are postoperative complications. The original problem coming back. General complications Pain It seems obvious that surgery will be painful, but modern expertise with painkillers and pain-blocking.
Patient information leaflet
Can I take Atenolol and Co-amoxiclav together?
Why this happens Atenolol is a beta-blocker used for heart conditions and blood pressure, while co-amoxiclav is a combination antibiotic (amoxicillin and clavulanic acid). Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Disclaimer This information.
Further reading and references
- RUNX1 partner transcriptional co-repressor 1; MedlinePlus, National Library of Medicine.
- Goyama S, Mulloy JC. Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. Int J Hematol. 2011 Aug;94(2):126-133. doi: 10.1007/s12185-011-0858-z. Epub 2011 May 3.
- Guo C, Hu Q, Yan C, Zhang J. Multivalent binding of the ETO corepressor to E proteins facilitates dual repression controls targeting chromatin and the basal transcription machinery. Mol Cell Biol. 2009 May;29(10):2644-57. doi: 10.1128/MCB.00073-09. Epub 2009 Mar 16.
- Lam K, Zhang DE. RUNX1 and RUNX1-ETO: roles in hematopoiesis and leukemogenesis. Front Biosci (Landmark Ed). 2012 Jan 1;17(3):1120-39. doi: 10.2741/3977.
Join the conversation
Share your thoughts or experiences with others in our patient communities.
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.