Paroxetine

About paroxetine

Paroxetine is prescribed for depression, anxiety disorders, and obsessive-compulsive disorder (OCD). Depression can develop for no apparent reason, or it can be triggered by a life event such as a relationship problem, a bereavement, or an illness. An anxiety disorder is a condition where anxiety is a major symptom. Panic disorder, social anxiety disorder, and post-traumatic stress disorder are all anxiety disorders. Obsessive-compulsive disorder (OCD) is a condition where you have recurring and persistent ideas that make you do repetitive actions.

Brain cells, called neurons, release a number of chemicals which go on to stimulate other neurons. This leads to electrical impulses which result in many functions controlled by the brain. Serotonin is one such chemical in the brain. Once released, it stimulates other neurons and is then taken back up into the neuron cells and recycled. Selective serotonin reuptake inhibitors (SSRIs) like paroxetine increase the amount of circulating serotonin available in your brain. Altering the balance of the chemicals in the brain can help with the symptoms of depression, anxiety disorders, and OCD.

Before taking paroxetine

Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking paroxetine it is important that your doctor knows:

• If you are pregnant, trying for a baby or breastfeeding.

• If you have any problems with the way your liver works, or with the way your kidneys work.

• If you have a heart condition.

• If you have epilepsy.

• If you have high blood sugar levels (diabetes mellitus).

• If you have an eye problem called glaucoma.

• If you have ever had a bleeding disorder.

• If you have ever had abnormally 'high' moods, called mania.

• If you are being treated with electroconvulsive therapy (ECT).

• If you have ever had an allergic reaction to a medicine.

• If you have taken an antidepressant known as a monoamine-oxidase inhibitor (MAOI) within the previous two weeks.

• If you are taking any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines.

How to take paroxetine

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about paroxetine and will provide you with a full list of the side-effects which you may experience from taking it.

• Take paroxetine exactly as your doctor tells you to. It is prescribed as a once-daily dose, to be taken in the morning. There are several strengths of paroxetine tablets - 10 mg, 20 mg, and 30 mg. Your doctor will tell you which strength is right for you.

• If you are being treated for a panic disorder, your doctor may prescribe a low dose for you to begin with, and then increase it. This is because some people feel anxious during the first two weeks, and slowly increasing the dose helps to reduce this.

• Take paroxetine with a snack or just after eating breakfast, as this will help to reduce the likelihood of you feeling sick as a side-effect. Swallow the tablets with a drink of water.

• If you are taking liquid medicine, it is recommended that you do not take indigestion remedies during the two hours before or during the two hours after you take paroxetine liquid. This is because antacids can reduce the amount of paroxetine your body absorbs.

• If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the missed dose. Do not take two doses together to make up for a forgotten dose.

Getting the most from your treatment

• You may feel that paroxetine is not working for you straightaway. It can take a week or two after starting the treatment before the effect begins to build up, and 4-6 weeks before you feel the full benefit. Do not stop taking it after a week or two, feeling it is not helping.

• Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress.

• While you are taking paroxetine, you may have thoughts about harming yourself or ending your life. These thoughts may also be associated with your condition. It is very important that you tell your doctor about this if it happens.

• Do not stop taking paroxetine unless your doctor tells you to do so. Stopping treatment suddenly can cause problems and your doctor will probably want you to reduce your dose gradually when this becomes necessary. You should expect that a course of treatment will last for several months. This is normal and helps to prevent your symptoms from recurring.

• If you drink alcohol, ask your doctor for advice. Your doctor is likely to recommend that you do not drink alcohol while you are on paroxetine.

• If you have diabetes, you may need to check your blood glucose more frequently, as paroxetine may affect the levels of sugar in your blood. Your doctor will advise you about this.

• If you buy any medicines, check with a pharmacist that they are safe to take with paroxetine. This is because several medicines which are available from general retail outlets can interfere with the treatment. In particular, do not take the herbal remedy St John's wort, and ask for advice before buying any anti-inflammatory painkillers.

• A few people taking paroxetine find that their skin is more sensitive to sunlight than normal. Until you know how your skin reacts, use a sun cream with a high sun protection factor (SPF) in strong sunlight.

• There are several types of antidepressants and they differ in their possible side-effects. If you find that paroxetine does not suit you then let your doctor know, as another may be found that will.

Can paroxetine cause problems?

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with paroxetine. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

If you experience any other symptoms that you think may be due to this medicine, speak with your doctor or pharmacist for further advice.

How to store paroxetine

• Keep all medicines out of the reach and sight of children.

• Store in a cool, dry place, away from direct heat and light.

• Once a bottle of Seroxat® Oral Suspension has been opened it will keep for one month - after this time, make sure you have a fresh supply.

Important information about all medicines