lysophosphatidic acid receptor 6
Last updated 12 Apr 2023
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The LPAR6 gene provides instructions for making a protein called lysophosphatidic acid receptor 6 (LPA6). This protein functions as a receptor. Receptor proteins have particular sites into which certain other proteins, called ligands, fit like keys into locks. A specific fat called lysophosphatidic acid (LPA) is the ligand for the LPA6 protein. LPA can attach to many receptors, but LPA6 is the only LPA receptor found in hair follicles. Hair follicles are specialized structures in the skin where hair growth occurs. As the cells in the hair follicle divide, the hair strand (shaft) is pushed upward and extends beyond the skin, causing the hair to grow. The LPA6 protein is also found in the outermost layer of skin (the epidermis). Attachment of LPA to LPA6 helps regulate the growth and division (proliferation) and maturation (differentiation) of cells in the hair follicle.
Normal function
The LPAR6 gene provides instructions for making a protein called lysophosphatidic acid receptor 6 (LPA6). This protein functions as a receptor. Receptor proteins have particular sites into which certain other proteins, called ligands, fit like keys into locks. A specific fat called lysophosphatidic acid (LPA) is the ligand for the LPA6 protein. LPA can attach to many receptors, but LPA6 is the only LPA receptor found in hair follicles. Hair follicles are specialized structures in the skin where hair growth occurs. As the cells in the hair follicle divide, the hair strand (shaft) is pushed upward and extends beyond the skin, causing the hair to grow. The LPA6 protein is also found in the outermost layer of skin (the epidermis). Attachment of LPA to LPA6 helps regulate the growth and division (proliferation) and maturation (differentiation) of cells in the hair follicle.
Conditions referring to this gene or chromosome
Other names
G-protein coupled purinergic receptor P2Y5
LPA receptor 6
LPA-6
LPAR6_HUMAN
oleoyl-L-alpha-lysophosphatidic acid receptor
P2RY5
P2Y purinoceptor 5
P2Y5
purinergic receptor 5
purinergic receptor P2Y G protein-coupled protein 5
purinergic receptor P2Y, G-protein coupled, 5
RB intron encoded G-protein coupled receptor
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Further reading and references
- lysophosphatidic acid receptor 6; MedlinePlus, National Library of Medicine.
- Azeem Z, Jelani M, Naz G, Tariq M, Wasif N, Kamran-Ul-Hassan Naqvi S, Ayub M, Yasinzai M, Amin-Ud-Din M, Wali A, Ali G, Chishti MS, Ahmad W. Novel mutations in G protein-coupled receptor gene (P2RY5) in families with autosomal recessive hypotrichosis (LAH3). Hum Genet. 2008 Jun;123(5):515-9. doi: 10.1007/s00439-008-0507-7. Epub 2008 May 7.
- Khan S, Habib R, Mir H, Umm-e-Kalsoom, Naz G, Ayub M, Shafique S, Yamin T, Ali N, Basit S, Wasif N, Kamran-Ul-Hassan Naqvi S, Ali G, Wali A, Ansar M, Ahmad W. Mutations in the LPAR6 and LIPH genes underlie autosomal recessive hypotrichosis/woolly hair in 17 consanguineous families from Pakistan. Clin Exp Dermatol. 2011 Aug;36(6):652-4. doi: 10.1111/j.1365-2230.2011.04014.x. Epub 2011 Mar 21.
- Kurban M, Wajid M, Shimomura Y, Christiano AM. Mutations in LPAR6/P2RY5 and LIPH are associated with woolly hair and/or hypotrichosis. J Eur Acad Dermatol Venereol. 2013 May;27(5):545-9. doi: 10.1111/j.1468-3083.2012.04472.x. Epub 2012 Mar 5.
- Pasternack SM, von Kugelgen I, Al Aboud K, Lee YA, Ruschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nurnberg P, Nothen MM, Betz RC. G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth. Nat Genet. 2008 Mar;40(3):329-34. doi: 10.1038/ng.84. Epub 2008 Feb 24.
- Shimomura Y, Wajid M, Ishii Y, Shapiro L, Petukhova L, Gordon D, Christiano AM. Disruption of P2RY5, an orphan G protein-coupled receptor, underlies autosomal recessive woolly hair. Nat Genet. 2008 Mar;40(3):335-9. doi: 10.1038/ng.100. Epub 2008 Feb 24.
- Tariq M, Ayub M, Jelani M, Basit S, Naz G, Wasif N, Raza SI, Naveed AK, ullah Khan S, Azeem Z, Yasinzai M, Wali A, Ali G, Chishti MS, Ahmad W. Mutations in the P2RY5 gene underlie autosomal recessive hypotrichosis in 13 Pakistani families. Br J Dermatol. 2009 May;160(5):1006-10. doi: 10.1111/j.1365-2133.2009.09046.x. Epub 2009 Mar 9.
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