Can I take Folic acid and Vitamin B12 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
Taking folic acid on its own can hide (mask) a vitamin B12 deficiency. If you have low B12 levels and take high doses of folic acid, it can fix the blood problems (like anaemia) but allow serious nerve damage to continue and get worse without being noticed.
Why this happens
Both folic acid and vitamin B12 are needed to make red blood cells. If you are low in B12, folic acid can 'bypass' the blockage in blood cell production, making your blood tests look normal. However, folic acid cannot fix the damage to the nervous system caused by low B12, which can lead to permanent nerve damage if the B12 deficiency isn't found and treated.
What you should do
Before starting a folic acid supplement, it is important to ensure your vitamin B12 levels are normal. If you are taking folic acid, your doctor should monitor your B12 levels regularly. If you experience numbness, tingling, or weakness in your hands or feet, speak to your doctor immediately.
Important precautions
Vitamin B12 deficiency (Pernicious Anaemia)
Folic acid can mask the symptoms of vitamin B12 deficiency. If you have B12 deficiency, taking folic acid alone can allow serious nerve damage to progress even though your blood count appears normal. Your doctor must ensure your B12 levels are checked before or during treatment.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol when taking these vitamins. Alcohol interferes with the body's ability to absorb and store both folic acid and vitamin B12, which can make your treatment less effective. Chronic alcohol use is a common cause of these vitamin deficiencies.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Mounjaro and Paracetamol together?
Mounjaro may slow down how quickly your body absorbs paracetamol. This means it might take longer for the paracetamol to start working to relieve pain or reduce a fever. However, the total amount of medicine that gets into your system should remain the same.

Drug interactions checker
Can I take Allopurinol and Nortriptyline together?
There is no known direct interaction between allopurinol and nortriptyline. However, both medications can occasionally cause side effects that affect the liver or blood counts. Taking them together does not typically increase these risks, but it is important to be aware of how you feel.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amlodipine and Paracetamol together?
- Can I take Ashwagandha and Folic acid together?
- Can I take Aspirin and Evolocumab together?
- Can I take Aspirin and Paracetamol together?
- Can I take Atorvastatin and Clarithromycin together?
- Can I take Atorvastatin and Colecalciferol together?
- Can I take Atorvastatin and Flecainide together?
- Can I take Candesartan and Collagen together?
- Can I take Citalopram and Co-codamol together?
- Can I take Co-codamol and Naproxen together?
- Can I take Fish oil and Vitamin D together?
- Can I take Iron supplements and Pregabalin together?
- Can I take Iron supplements and Vitamin D together?
- Can I take Lansoprazole and Tamsulosin together?
- Can I take Levothyroxine and Prednisolone together?
- Can I take Losartan and Turmeric together?
- Can I take Magnesium and Warfarin together?
- Can I take Magnesium and Wegovy flextouch together?
- Can I take Naproxen and Uribel together?
- Can I take Statins and Grapefruit together?