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Can I take Folic acid and St john's wort together?

Drug interaction guide

There is no known significant interaction between folic acid and St John's Wort. It is generally considered safe to take these two together.

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Why this happens

Folic acid is a water-soluble B vitamin, while St John's Wort is an herbal remedy primarily used for low mood. They are processed by different pathways in the body and do not interfere with each other's absorption, metabolism, or effectiveness.

What you should do

You can continue to take both as directed. However, always inform your doctor or pharmacist if you are taking St John's Wort, as it interacts with many other prescription medicines (such as the contraceptive pill, blood thinners, and antidepressants).

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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