Can I take Folic acid and Oestrogel pump-pack together?

Why this happens

Folic acid is a B vitamin used by the body to make healthy cells, while Oestrogel is a hormone replacement therapy (HRT) that provides oestradiol through the skin. These substances are processed by the body through different pathways and do not interfere with how the other is absorbed, used, or cleared from the system.

What you should do

You can continue to take your folic acid supplement and use your Oestrogel pump-pack as prescribed by your doctor. No special precautions or timing changes are necessary.

Important precautions

Vitamin B12 deficiency (Pernicious Anaemia)

Folic acid can mask the symptoms of vitamin B12 deficiency. If you have B12 deficiency, taking folic acid alone can allow serious nerve damage to progress even though your blood count appears normal. Your doctor must ensure your B12 levels are checked before or during treatment.

Breast cancer or blood clots

You must not use Oestrogel if you have ever had breast cancer, or if you have ever had a blood clot in a vein (thrombosis) or a blood clotting disorder.

Intact uterus (womb)

If you still have your womb, you must also take a progestogen medicine alongside Oestrogel to prevent the lining of the womb from thickening excessively, which increases the risk of cancer.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking these medicines. For folic acid, alcohol can interfere with how the vitamin is absorbed and stored in the body, making the treatment less effective. For Oestrogel, alcohol can increase oestrogen levels in the blood, which may increase the risk of side effects.

Grapefruit and grapefruit juice

Grapefruit can increase the levels of oestrogen in your body by slowing down how your liver breaks it down. This may increase the risk of side effects such as breast tenderness, nausea, or bloating. It is best to avoid consuming large amounts of grapefruit while using this medicine.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.