Can I take Folic acid and Oestrogel pump-pack /actuation together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known harmful interaction between folic acid and Oestrogel (estradiol). It is safe to use these two treatments together.
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Why this happens
Folic acid is a B vitamin used by the body to make healthy cells, while Oestrogel is a hormone replacement therapy (HRT) that provides estradiol through the skin. These substances are processed by the body through different pathways and do not interfere with how the other is absorbed, used, or cleared from the system.
What you should do
You can continue to take your folic acid supplement and use your Oestrogel pump-pack as prescribed by your doctor. No special precautions or timing changes are necessary.
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Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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