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Can I take Alendronic acid and Lansoprazole together?

Drug interaction guide

Taking lansoprazole may make alendronic acid less effective at strengthening your bones. There is also a slightly higher risk of developing certain types of bone fractures (such as hip or wrist fractures) when these two types of medicines are used together over a long period.

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Why this happens

Alendronic acid needs a certain level of stomach acid to be absorbed properly. Lansoprazole works by reducing stomach acid, which can interfere with how well the alendronic acid is taken up by your body. Additionally, both drugs can independently affect bone density when used long-term.

What you should do

You can take these medicines together, but it is vital to follow the specific timing instructions for alendronic acid. Take your alendronic acid first thing in the morning on an empty stomach with a full glass of plain water, at least 30 minutes before taking lansoprazole or eating any food. Your doctor may also monitor your bone density more closely or ensure you have enough calcium and vitamin D.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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