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Can I take Losartan and Sertraline together?

Drug interaction guide

Taking these two medicines together can sometimes cause your blood pressure to drop lower than intended. This might make you feel dizzy, lightheaded, or faint, especially when you stand up quickly. There is also a small risk that the combination could affect the levels of sodium (salt) in your blood.

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Why this happens

Both medicines can independently lower blood pressure. Losartan is designed to do this, while sertraline can sometimes cause low blood pressure as a side effect. Additionally, both drugs are linked to a condition called hyponatraemia (low blood sodium), particularly in older patients.

What you should do

It is generally safe to take these together, but you should be mindful of how you feel. If you feel dizzy or lightheaded, sit or lie down until the feeling passes. Rise slowly from a sitting or lying position. If you experience persistent dizziness, confusion, or extreme tiredness, mention it to your doctor, as they may want to check your blood pressure or perform a simple blood test to check your salt levels.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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