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Can I take Eplerenone and Paracetamol together?

Drug interaction guide

There is no known interaction between eplerenone and paracetamol. It is generally considered safe to take these two medicines together.

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Why this happens

Eplerenone and paracetamol are processed by different pathways in the body. Eplerenone is a diuretic (water tablet) that works on the kidneys to help with heart conditions, while paracetamol is a painkiller processed mainly by the liver. They do not interfere with how each other works or how they are cleared from the system.

What you should do

You can take paracetamol while using eplerenone. Always follow the dosage instructions on the packet for paracetamol and do not exceed the maximum daily dose. If you have severe kidney or liver problems, you should always check with your doctor before taking any new medicines.

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Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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