Can I take Fish oil and Vitamin D together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
There is no negative interaction between fish oil and vitamin D. In fact, taking them together is often beneficial. Vitamin D is a fat-soluble vitamin, meaning it needs fat to be absorbed properly by your body. The healthy fats (omega-3 fatty acids) in fish oil can actually help your body absorb the vitamin D more effectively.
In this article:
Video picks for Drug interactions
Continue reading below
Why this happens
Vitamin D requires dietary fat for optimal absorption in the small intestine. Fish oil provides a concentrated source of lipids that facilitates the formation of micelles, which are necessary for the transport of vitamin D into the bloodstream.
What you should do
Back to contentsIt is perfectly safe and often recommended to take these two supplements together. For the best results, take them with your largest meal of the day to further aid absorption.
Continue reading below
Important precautions
Back to contentsBleeding disorders or use of blood-thinning medication (e.g. warfarin)
High doses of fish oil can have an antiplatelet effect, which may increase your risk of bleeding or bruising if you already take blood thinners or have a bleeding disorder.
Hypercalcaemia (high blood calcium levels)
You must not take vitamin D supplements if you have high levels of calcium in your blood or urine, as vitamin D increases calcium absorption and can lead to serious kidney damage or heart rhythm issues.
Food and drink warnings
Back to contentsAlcohol
It is best to avoid or strictly limit alcohol when taking these supplements. Excessive alcohol consumption can interfere with how your body absorbs and processes Vitamin D and may increase the risk of stomach irritation when taken with fish oil.
High-fat meals
Both Vitamin D and Fish Oil are fat-soluble. Taking them with a meal that contains some fat (such as yoghurt, eggs, or avocado) significantly improves how well your body absorbs the supplements.
Continue reading below
Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions
Treatment and medication
Can I take Levothyroxine and Vitamin D together?
There is no direct harmful interaction between levothyroxine and vitamin D. In fact, many people take them together because vitamin D deficiency is common in people with thyroid conditions. However, if your vitamin D supplement also contains calcium, it can significantly interfere with how your body absorbs your thyroid medication.
Treatment and medication
Can I take Levothyroxine and Simvastatin together?
Taking these two medicines together is generally safe, but levothyroxine can affect how well simvastatin works. If your thyroid levels are not properly controlled (hypothyroidism), simvastatin may be less effective at lowering your cholesterol, and you may be at a slightly higher risk of muscle-related side effects from the statin.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published
Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.
Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.