Can I take Evening primrose oil and Vitamin C together?

Why this happens

Evening primrose oil is a source of omega-6 fatty acids (specifically gamma-linolenic acid), while vitamin C is a water-soluble antioxidant. They are processed by the body through different pathways and do not interfere with each other's absorption, metabolism, or effectiveness. In fact, some evidence suggests that antioxidants like vitamin C may help protect the fatty acids in evening primrose oil from oxidising (breaking down) in the body.

What you should do

You can continue to take both supplements as directed. As with any supplement, it is best to take them with food to reduce the chance of an upset stomach. If you have any underlying health conditions or are taking prescribed medications (especially blood thinners or epilepsy medication), consult your pharmacist or doctor before starting new supplements.

Important precautions

Epilepsy or Schizophrenia

Evening primrose oil may increase the risk of seizures, particularly in people with a history of epilepsy or those taking phenothiazine medications for schizophrenia.

Bleeding disorders or upcoming surgery

Evening primrose oil can thin the blood and increase the risk of bruising or bleeding. You must stop taking it at least two weeks before any scheduled surgery.

Kidney stones or kidney disease

High doses of vitamin C can increase the amount of oxalate in your urine, significantly raising the risk of developing kidney stones.

G6PD deficiency

If you have glucose-6-phosphate dehydrogenase (G6PD) deficiency, high doses of vitamin C can cause your red blood cells to break down (haemolysis).

Haemochromatosis

Vitamin C increases the absorption of iron from your food. If you have an iron-overload disorder like haemochromatosis, you should avoid high-dose supplements.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol when taking evening primrose oil. While there is no direct chemical interaction, both substances can lower the seizure threshold in susceptible individuals, and alcohol may worsen the side effects of the supplement, such as nausea or indigestion.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.