Can I take Fexofenadine and Pregabalin together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
Both fexofenadine and pregabalin can cause drowsiness, dizziness, and blurred vision. Taking them together may increase these side effects, making you feel more tired or less alert than usual.
In this article:
Continue reading below
Why this happens
This is an 'additive' effect. While fexofenadine is a non-drowsy antihistamine, it can still cause mild sleepiness in some people. Pregabalin commonly affects the central nervous system. When combined, their individual effects on your alertness can add together.
What you should do
It is generally safe to take these together, but you should be cautious when you first start the combination. See how they affect you before driving or using machinery. If you feel very drowsy or dizzy, speak to your pharmacist or doctor.
Continue reading below
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Treatment and medication
Can I take Idapamide and Ramipril together?
Taking indapamide and ramipril together can cause your blood pressure to drop too low, especially when you first start the combination. This can make you feel dizzy, lightheaded, or faint. It can also put extra strain on your kidneys.

Treatment and medication
Can I take Clarithromycin and Rosuvastatin together?
Taking these two medicines together can significantly increase the amount of rosuvastatin in your blood. This increases the risk of serious muscle damage (rhabdomyolysis), which can lead to kidney problems. Symptoms to watch for include unexplained muscle pain, tenderness, or weakness, especially if you also feel generally unwell or have a fever.
Continue reading below
Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.