Can I take Losartan and Vitamin B12 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
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There is no known interaction between losartan and vitamin B12. It is generally safe to take these two together.
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Why this happens
Losartan is a blood pressure medication (angiotensin II receptor blocker) and vitamin B12 is a water-soluble vitamin. They are processed by the body through different pathways and do not interfere with each other's absorption, metabolism, or effectiveness.
What you should do
Back to contentsYou can continue taking both as prescribed. As with any supplement, it is always a good idea to inform your doctor or pharmacist about everything you are taking to ensure your records are up to date.
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Important precautions
Back to contentsPregnancy
You must not take losartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters.
Food and drink warnings
Back to contentsAlcohol
It is best to avoid or strictly limit alcohol while taking losartan. Alcohol can increase the blood pressure-lowering effect of losartan, which may make you feel dizzy, lightheaded, or faint, especially when standing up. Combining alcohol with medication also increases the risk of liver damage.
It is best to avoid or strictly limit alcohol while taking Vitamin B12. Heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut and can reduce the amount of the vitamin stored in the liver.
Potassium-rich foods (e.g., bananas, spinach, salt substitutes)
Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of potassium-rich foods, as high potassium levels can affect your heart rhythm.
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Using other medicines
Back to contentsTaking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
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Treatment and medication
Can I take Losartan and Metformin together?
Taking losartan and metformin together is generally safe, but it may slightly increase the risk of your blood sugar levels dropping too low (hypoglycaemia). Additionally, both drugs can affect your kidney function, especially if you become dehydrated.

Treatment and medication
Can I take Losartan and Pregabalin together?
Both medications can cause drowsiness, dizziness, and a drop in blood pressure. Taking them together may increase the risk of feeling lightheaded, sleepy, or unsteady on your feet, which could lead to falls. Some patients may also experience increased swelling (fluid retention) in the legs or feet.
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Article history
The information on this page is written and peer reviewed by qualified clinicians.
25 Jan 2026 | Originally published

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