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Can I take Losartan and Vitamin B12 together?

Drug interaction guide

There is no known interaction between losartan and vitamin B12. It is generally safe to take these two together.

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Why this happens

Losartan is a blood pressure medication (angiotensin II receptor blocker) and vitamin B12 is a water-soluble vitamin. They are processed by the body through different pathways and do not interfere with each other's absorption, metabolism, or effectiveness.

You can continue taking both as prescribed. As with any supplement, it is always a good idea to inform your doctor or pharmacist about everything you are taking to ensure your records are up to date.

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Pregnancy

You must not take losartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters.

Alcohol

It is best to avoid or strictly limit alcohol while taking losartan. Alcohol can increase the blood pressure-lowering effect of losartan, which may make you feel dizzy, lightheaded, or faint, especially when standing up. Combining alcohol with medication also increases the risk of liver damage.

It is best to avoid or strictly limit alcohol while taking Vitamin B12. Heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut and can reduce the amount of the vitamin stored in the liver.

Potassium-rich foods (e.g., bananas, spinach, salt substitutes)

Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of potassium-rich foods, as high potassium levels can affect your heart rhythm.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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