Can I take Losartan and Vitamin B12 together?
Drug interaction guide
Originally published 25 Jan 2026
Meets Patient’s editorial guidelines
- DownloadDownload
- Share
- Language
- Discussion
- Audio Version
- Add to preferred sources on Google
There is no known interaction between losartan and vitamin B12. It is generally safe to take these two together.
Why this happens
Losartan is a blood pressure medication (angiotensin II receptor blocker) and vitamin B12 is a water-soluble vitamin. They are processed by the body through different pathways and do not interfere with each other's absorption, metabolism, or effectiveness.
What you should do
You can continue taking both as prescribed. As with any supplement, it is always a good idea to inform your doctor or pharmacist about everything you are taking to ensure your records are up to date.
Important precautions
Pregnancy
You must not take losartan if you are pregnant. It can cause serious harm or death to an unborn baby, especially if taken during the second and third trimesters.
Food and drink warnings
Alcohol
It is best to avoid or strictly limit alcohol while taking losartan. Alcohol can increase the blood pressure-lowering effect of losartan, which may make you feel dizzy, lightheaded, or faint, especially when standing up. Combining alcohol with medication also increases the risk of liver damage.
It is best to avoid or strictly limit alcohol while taking Vitamin B12. Heavy alcohol consumption can interfere with the body's ability to absorb Vitamin B12 from the gut and can reduce the amount of the vitamin stored in the liver.
Potassium-rich foods (e.g., bananas, spinach, salt substitutes)
Losartan can increase the levels of potassium in your blood. You should avoid using salt substitutes containing potassium (such as Lo-Salt) and speak to your doctor before significantly increasing your intake of potassium-rich foods, as high potassium levels can affect your heart rhythm.
Using other medicines
Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.
Disclaimer
This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.
Patient picks for Drug interactions

Drug interactions checker
Can I take Guanfacine and Tizanidine together?
Taking these two medicines together can cause your blood pressure to drop too low and make you feel very sleepy or dizzy. You may feel faint, lightheaded, or even pass out, especially when standing up quickly. It can also significantly slow your heart rate.

Drug interactions checker
Can I take Warfarin and Aspirin together?
Taking warfarin and aspirin together significantly increases your risk of serious bleeding. This includes internal bleeding, such as in the stomach or brain, as well as bleeding that is hard to stop from minor cuts or injuries.
Article history
The information on this page is written and peer reviewed by qualified clinicians.
Article also available in English, German, Spanish, French, Italian, Portuguese, Hindi, Hebrew, Arabic, and Swedish.
25 Jan 2026 | Originally published

Ask, share, connect.
Browse discussions, ask questions, and share experiences across hundreds of health topics.

Feeling unwell?
Assess your symptoms online for free
Sign up to the Patient newsletter
Your weekly dose of clear, trustworthy health advice - written to help you feel informed, confident and in control.
By subscribing you accept our Privacy Policy. You can unsubscribe at any time. We never sell your data.
More in drug interactions checker
- Can I take Amitriptyline and Paracetamol together?
- Can I take Amlodipine and Aspirin 300 together?
- Can I take Anastrozole and Simvastatin together?
- Can I take antihistamines while pregnant?
- Can I take Apixaban and Losartan together?
- Can I take Aspirin and Paracetamol together?
- Can I take Atenolol and Rybelsus (semaglutide) together?
- Can I take Candesartan and Nortriptyline together?
- Can I take Chaga and Maitake together?
- Can I take Ciprofloxacin and Doxycycline together?
- Can I take Devil's claw and Rosehip together?
- Can I take Eplerenone and Lixiana together?
- Can I take Esomeprazole and Sertraline together?
- Can I take Evening primrose oil and Ginger together?
- Can I take Fexofenadine and Pregabalin together?
- Can I take Magnesium and Vitamin B2 together?
- Can I take Magnesium and Warfarin together?
- Can I take Metformin and Clopidogrel together?
- Can I take Sedoxil and Venlafaxine together?