Can I take Amlodipine and Aspirin 300 together?

Why this happens

Aspirin belongs to a group of medicines called NSAIDs. These can cause the body to hold onto salt and water, which works against amlodipine's job of lowering blood pressure. Additionally, both medicines can affect blood flow and the lining of the stomach.

What you should do

It is generally safe to take these together occasionally, but you should monitor your blood pressure regularly. If you need to take 300mg of aspirin frequently, speak to your GP or pharmacist, as they may prefer you to use a different painkiller like paracetamol which does not affect blood pressure. Seek medical advice if you notice any unusual bruising or dark, tarry stools.

Important precautions

Asthma

Do not take aspirin if you have a history of asthma triggered by aspirin or other non-steroidal anti-inflammatory drugs (NSAIDs), as it can cause a severe, life-threatening asthma attack.

Stomach ulcers or bleeding disorders

Avoid aspirin if you have an active stomach ulcer or a history of bleeding problems, as it significantly increases the risk of serious internal bleeding.

Food and drink warnings

Grapefruit juice

Grapefruit juice can increase the amount of amlodipine in your body and may cause your blood pressure to drop too low. It is best to avoid drinking large amounts of grapefruit juice while taking this medicine.

Alcohol

Drinking alcohol while taking aspirin can increase the risk of irritation and bleeding in your stomach. It is best to limit alcohol intake or avoid it if you have a sensitive stomach.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.