Can I take Colecalciferol and Fexofenadine together?

Why this happens

Colecalciferol (Vitamin D3) is a fat-soluble vitamin processed by the liver and kidneys to help the body absorb calcium. Fexofenadine is a non-drowsy antihistamine that is mostly excreted unchanged by the body. They do not share the same metabolic pathways or interfere with each other's absorption or effects.

What you should do

You can continue to take both medications as prescribed by your doctor or as directed on the packaging. No special precautions are needed.

Important precautions

Hypercalcaemia (high blood calcium)

Do not take colecalciferol if you have high levels of calcium in your blood or urine, or if you have severe kidney stones, as vitamin D increases calcium absorption and can worsen these conditions.

Indigestion remedies (antacids)

Do not take indigestion remedies containing aluminium or magnesium within 2 hours of taking this medicine, as they will stop the fexofenadine from being absorbed properly.

Food and drink warnings

Alcohol

It is best to avoid or strictly limit alcohol while taking colecalciferol. Long-term heavy alcohol use can interfere with how your body absorbs and processes Vitamin D, making the treatment less effective.

It is best to avoid or strictly limit alcohol while taking fexofenadine. Although fexofenadine is a non-drowsy antihistamine, alcohol can increase the risk of side effects like dizziness or sleepiness, which may impair your ability to perform tasks safely.

High-fat meals

Colecalciferol is a fat-soluble vitamin. It is best absorbed by your body when taken with a meal that contains some fat (such as eggs, avocado, nuts, or dairy).

Fruit juices (Grapefruit, Orange, Apple)

Do not drink grapefruit juice, orange juice, or apple juice while taking fexofenadine. These juices can significantly reduce the amount of medicine absorbed by your body, making it less effective. It is best to take fexofenadine with water.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.