Can I take Atorvastatin and Metformin together?

It is safe to take atorvastatin and metformin together as they are processed by different pathways in the body and do not interfere with each other.

Atorvastatin is primarily broken down by the liver (CYP3A4 enzyme), while metformin is cleared by the kidneys.

How to take atorvastatin and metformin safely

• Take these medications exactly as prescribed by your doctor.

• It is important to continue taking both to manage your heart health and blood sugar levels.

• If you experience unusual muscle pain or weakness (a rare side effect of statins), you should still report this to your doctor.

• Metformin should be taken with or immediately after a meal. This helps to significantly reduce common digestive side effects such as nausea, stomach upset, and diarrhoea.

Important precautions

Pregnancy

You must not take atorvastatin if you are pregnant or planning to become pregnant, as it can cause serious harm to an unborn baby. Use effective contraception while taking this medicine.

Muscle disorders - atorvastatin

Seek immediate medical advice if you experience unexplained muscle pain, tenderness, or weakness. In rare cases, this can lead to a serious condition called rhabdomyolysis which causes kidney damage.

Severe dehydration or infection

Stop taking metformin and seek urgent medical help if you develop severe vomiting, diarrhoea, or a high fever. These can lead to a rare but serious condition called lactic acidosis.

Food and drink warnings

Grapefruit juice

Grapefruit juice contains compounds that can increase the level of atorvastatin in your blood. This may increase your risk of side effects, such as muscle pain or damage.

Avoid drinking large quantities (more than 1.2 litres per day), though it is safest to avoid it altogether or keep intake to very small amounts.

Alcohol

For Atorvastatin: Drinking large amounts of alcohol regularly can increase the risk of liver problems and muscle side effects.

For Metformin: You should avoid excessive alcohol intake (binge drinking). Alcohol increases the risk of a rare but serious complication called lactic acidosis, and it can also increase the risk of low blood sugar (hypoglycaemia).

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.