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Can I take Collagen and Omega-3 together?

Drug interaction guide

There are no known harmful interactions between collagen and omega-3 supplements. In fact, they are often taken together to support skin, joint, and heart health.

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Why this happens

Collagen is a protein that is broken down into amino acids in the digestive tract, while omega-3 is a fatty acid. They use different pathways for absorption and metabolism in the body and do not interfere with how the other works.

It is safe to take these two supplements together. For the best absorption, take your omega-3 with a meal that contains some fat. Always follow the dosage instructions on the product labels and inform your doctor about any supplements you are taking.

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Fish, shellfish, or egg allergies

Many collagen supplements are derived from marine or avian sources. Check the label carefully, as these can trigger severe allergic reactions in people with existing food allergies.

Bleeding disorders or surgery

High doses of omega-3 can thin the blood and increase the risk of bleeding. You must stop taking these supplements at least two weeks before any planned surgery and use caution if you are already taking blood-thinning medication like warfarin.

Alcohol

It is best to avoid or strictly limit alcohol while taking omega-3 supplements. Both alcohol and high doses of omega-3 can have blood-thinning effects; combining them may increase the risk of bruising or bleeding. Additionally, alcohol can raise triglyceride levels, which may counteract the benefits of the supplement.

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Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.

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Article history

The information on this page is written and peer reviewed by qualified clinicians.

  • 25 Jan 2026 | Originally published
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