Can I take Esomeprazole and Vitamin b12 together?

Why this happens

Vitamin B12 needs stomach acid to be released from the proteins in your food so it can be absorbed. Esomeprazole works by reducing the amount of acid your stomach produces. Less acid means less vitamin B12 is released and absorbed into your system.

What you should do

If you take esomeprazole long-term (more than 2 or 3 years), talk to your doctor about your vitamin B12 levels. They may suggest a simple blood test or a supplement. If you already take B12 supplements or injections, this interaction is less of a concern as these forms are usually absorbed more easily.

Important precautions

Severe diarrhoea

Esomeprazole can increase your risk of developing a serious bowel infection caused by Clostridium difficile. If you develop severe, watery, or persistent diarrhoea, seek medical advice immediately.

Lupus (SCLE)

This medicine can rarely cause a specific skin reaction called Subacute Cutaneous Lupus Erythematosus. If you develop a skin rash, especially in areas exposed to the sun, or joint pain, you must inform your doctor as you may need to stop the treatment.

Food and drink warnings

Alcohol

While alcohol does not directly interact with esomeprazole, it can increase stomach acid production and irritate the stomach lining, which may worsen the symptoms you are taking esomeprazole to treat. It is best to limit or avoid alcohol if you have acid-related issues.

Caffeine (Coffee, Tea, Energy Drinks)

Caffeine can trigger or worsen symptoms of acid reflux and heartburn. If you are taking esomeprazole for these conditions, you may find that reducing caffeine intake helps the medicine work more effectively.

Using other medicines

Taking multiple medicines? Our Medicines Interaction Checker helps you check whether your prescriptions, over-the-counter medicines, and supplements are safe to take together. Simply search for your medicines to see potential interactions and what to do about them.

Disclaimer

This information is for general educational purposes only and should not be relied upon as a substitute for professional medical advice. Always consult your GP, pharmacist, or another qualified healthcare professional before making decisions about your medications. Individual circumstances may vary, and only a healthcare professional who knows your medical history can provide personalised guidance.