Avanafil is for the treatment of adult men with erectile dysfunction.
Take a tablet around 15 to 30 minutes before you plan to have sex. Do NOT take more than one dose in 24 hours.
When you collect your prescriptions, check the strength of the tablets. If they are a different strength to what you are expecting, speak with your doctor or pharmacist for further advice.
|Type of medicine||Phosphodiesterase type-5 inhibitor|
|Used for||Erectile dysfunction in adult men|
Erectile dysfunction (sometimes called impotence) means that you cannot get or maintain a proper erection. There are several causes, the most common being due to a narrowing of the arteries that take blood to the penis.
Avanafil works by preventing the action of a chemical in your body, called phosphodiesterase type-5. This helps to widen (relax) blood vessels and improves the flow of blood to the penis following sexual stimulation. This helps to maintain an erection.
Avanafil is available on prescription, but it is only prescribed on the NHS for men with erectile dysfunction resulting from certain medical conditions. If you are given a private (non-NHS) prescription, you will be asked to pay for the full cost of the tablets.
Before taking avanafil
Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. For these reasons, before you start taking avanafil it is important that your doctor knows:
- If you have any disease, injury or deformity of your penis.
- If you have an irregular heartbeat, a heart condition, or blood vessel disease.
- If you have had an eye condition causing loss of vision.
- If you have high or low blood pressure, or angina.
- If you have any problems with the way your liver works or with the way your kidneys work.
- If you have had a stroke or a heart attack.
- If you have a condition which causes bleeding, such as a stomach ulcer.
- If you have sickle cell disease.
- If you have ever had bone marrow cancer or leukaemia.
- If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, as well as herbal and complementary medicines, and recreational drugs.
- If you have ever had an allergic reaction to a medicine.
How to take avanafil tablets
- Before you take avanafil, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about the tablets and will provide you with a full list of the side-effects which you may experience from taking them.
- Take avanafil exactly as your doctor tells you to. It is intended to be taken before sexual activity - it is NOT for continuous daily use. You should take one tablet about 15-30 minutes before you plan to have sex. You can take the tablet either before or after food but, if you have just eaten a meal, it may take longer for it to work.
- There are three strengths of avanafil tablets: 50 mg, 100 mg and 200 mg. It is likely that you will be given the 100 mg strength tablet to begin with, but this may be changed subsequently depending upon how you react. Each time you collect a prescription, check to make sure it contains the strength of tablet you are expecting.
- Do not take more than one dose of avanafil in any 24-hour period.
Getting the most from your treatment
- You and your partner will still need to engage in foreplay, just as you would if you were not taking a medicine for erectile dysfunction. Avanafil will not cause an erection unless you are sexually aroused.
- Do not drink large amounts of alcohol before you plan to take avanafil. Drinking too much alcohol can reduce your ability to get an erection and this may prevent you from getting the maximum benefit from the tablets. The combination of avanafil and alcohol will also increase your risk of side-effects such as dizziness.
- It is recommended that you do not drink grapefruit juice during the 24 hours before you take avanafil. This is because there is a chemical in grapefruit juice which can increase the amount of avanafil in your bloodstream and this makes side-effects more likely.
- Keep your regular appointments with your doctor so your progress can be monitored. If you feel the tablets are too strong for you, discuss this with your doctor as your dose may need to be reduced. Alternatively, if you do not get an erection after taking avanafil, or if it does not last long enough for you to have sex, you should discuss this with your doctor - do not take more tablets than you have been told to.
- You should not take avanafil if you are using any other products or taking any other medicines to treat erectile dysfunction.
Can avanafil cause problems?
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with avanafil. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
|Common avanafil side-effects (these affect fewer than 1 in 10 men)||What can I do if I experience this?|
|Headache||Drink plenty of water. If the headaches continue, let your doctor know|
|Flushing, blocked nose||These should soon pass|
Important: if your erection lasts for longer than four hours, or if you get chest pains or a sudden loss of vision or hearing, contact a doctor for medical attention straightaway.
If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.
How to store avanafil
- Keep all medicines out of the reach and sight of children.
- Store in a cool, dry place, away from direct heat and light.
Important information about all medicines
If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.
Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.
If you are having an operation or dental treatment, tell the person carrying out the treatment which medicines you are taking.
This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.
Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.
If you have any questions about this medicine ask your pharmacist.
Further reading and references
Manufacturer's PIL, Spedra® 50 mg, 100 mg and 200 mg tablets; A. Menarini Farmaceutica Internazionale SRL, The electronic Medicines Compendium. Dated October 2020.
British National Formulary, 80th Edition (Sep 2020); British Medical Association and Royal Pharmaceutical Society of Great Britain, London.