Febuxostat to prevent gout attacks (Adenuric)

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Febuxostat is prescribed to help prevent gout attacks. It does not have any effect during a gout attack, although you should continue to take it regularly every day, even if this happens. A painkilling medicine or colchicine will be prescribed for you to take alongside it should you get a gout attack.

Take one tablet each day.

There have been a few reports of febuxostat causing a serious allergic reaction (such as swelling around the face, difficulties breathing and skin rash). Although this is rare, if you experience any of these symptoms, you should stop taking febuxostat and contact your doctor straightaway.

Type of medicineA xanthine-oxidase inhibitor
Used forTo prevent attacks of gout
Also calledAdenuric®
Available asTablets

Gout causes attacks of painful inflammation in one or more of your joints. It is caused by a build-up of a naturally-occurring chemical in your blood, called uric acid (urate). From time to time, the level of uric acid in your blood may become too high and tiny grit-like crystals may form, which typically collect in your joints and tendons. The crystals irritate the tissues of the joint to cause inflammation, swelling and pain.

If you have had a number of gout attacks, your doctor may advise that you take a medicine known as a xanthine-oxidase inhibitor to help prevent more attacks from occurring. There are two of these types of medicines currently available - allopurinol and febuxostat. You will have been prescribed febuxostat if allopurinol is unsuitable for you. Febuxostat helps to prevent gout attacks by reducing the levels of uric acid in your blood. However, it does not have any painkilling effect during a gout attack, so you will still need to take pain relief should you have any further attacks. In this case, your doctor will prescribe either an anti-inflammatory painkiller or colchicine for you to take alongside febuxostat.

Some medicines are not suitable for people with certain conditions, and sometimes a medicine can only be used if extra care is taken. For these reasons, before you start taking febuxostat it is important that your doctor knows:

  • If you are pregnant or breast-feeding.
  • If you have a heart condition, such as heart disease or heart failure.
  • If you have any problems with your thyroid, liver or kidneys.
  • If you have had an organ transplant. (This is because no studies have been done with this group of people.)
  • If you are taking or using any other medicines. This includes any medicines you are taking which are available to buy without a prescription, such as herbal and complementary medicines.
  • If you have ever had an allergic reaction to a medicine.
  • Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about febuxostat and will provide you with a full list of the side-effects which you may experience from taking it.
  • If you have recently had a gout attack, make sure your symptoms have completely gone before you start taking febuxostat tablets.
  • Take febuxostat exactly as your doctor tells you to. Take one tablet each day.
  • There are two strengths of tablet - 80 mg and 120 mg. When starting the treatment, your doctor will give you 80 mg strength tablets. The strength of the tablet may be increased after 2-4 weeks to 120 mg, if this is necessary. Your dose will be adjusted in line with how much uric acid is in your blood.
  • You can take febuxostat at whatever time of day you find easiest to remember, although most people choose to take it in a morning. Try to take your doses at the same time of day each day, as this will help you to take it regularly. You can take the tablet either before or after meals.
  • If you forget to take a dose, take it as soon as you remember. If you do not remember until the following day, skip the forgotten dose. Do not take two doses at the same time to make up for a missed dose.
  • Try to keep your regular appointments with your doctor. This is so your doctor can check on your progress. Your doctor will want you to have a blood test to check that the level of uric acid has come down. This is is often done two weeks or so after starting febuxostat. You will also need to have blood tests from time to time to check that your liver stays healthy.
  • Remember, febuxostat should be taken every day to prevent a gout attack. It can take six months to become fully effective. It does not have any effect during a gout attack, although you should continue to take it regularly every day even if this happens.
  • During the first few months of taking febuxostat, your blood levels of uric acid may rise for a short while before they fall. This can cause a gout attack. Your doctor will prescribe an anti-inflammatory treatment or colchicine tablets for you to take alongside febuxostat during this time.
  • Treatment with febuxostat is usually long-term unless you experience an adverse effect. Continue to take the tablets unless you are advised otherwise by a doctor.
  • There are a number of lifestyle changes that you can make to help reduce the risk of having a gout attack. These include losing weight (if you are overweight), eating a healthy diet and not drinking much alcohol or sugar-sweetened soft drinks. Your doctor will advise you about the changes which could benefit you.

Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with febuxostat. You will find a full list in the manufacturer's information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

Common febuxostat side-effects (these affect less than 1 in 10 people)What can I do if I experience this?
DiarrhoeaDrink plenty of water to replace lost fluids. If this continues or becomes troublesome, let your doctor know
HeadacheAsk your pharmacist to recommend a suitable painkiller
Feeling sickStick to simple meals - avoid rich or spicy food
Swollen feet and anklesSpeak with your doctor about this
Changes to some blood test resulsYour doctor will check for these

Important: there have been a few reports of febuxostat causing a serious allergic reaction (such as swelling around the face, difficulties breathing, swollen glands and skin rash). Although this is rare, if you experience any of these symptoms, you should stop taking febuxostat and contact your doctor straightaway.

If you experience any other symptoms which you think may be due to the tablets, speak with your doctor or pharmacist for further advice.

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.

Never take more than the prescribed dose. If you suspect that you or someone else might have taken an overdose of this medicine, go to the accident and emergency department of your local hospital. Take the container with you, even if it is empty.

This medicine is for you. Never give it to other people even if their condition appears to be the same as yours.

If you buy any medicines 'over-the-counter', always check with a pharmacist that they are suitable for you to take alongside your other medicines.

If you are having an operation or any dental treatment, tell the person carrying out the treatment which medicines you are taking.

Do not keep out-of-date or unwanted medicines. Take them to your local pharmacy which will dispose of them for you.

If you have any questions about this medicine ask your pharmacist.

Further reading & references

  • Manufacturer's PIL, Adenuric® film-coated tablets; A. Menarini Farmaceutica Internazionale SRL, The electronic Medicines Compendium. Dated February 2014.
  • British National Formulary; 69th Edition (Mar 2015) British Medical Association and Royal Pharmaceutical Society of Great Britain, London

Disclaimer: This article is for information only and should not be used for the diagnosis or treatment of medical conditions. EMIS has used all reasonable care in compiling the information but make no warranty as to its accuracy. Consult a doctor or other health care professional for diagnosis and treatment of medical conditions. For details see our conditions.

Original Author:
Helen Allen
Current Version:
Peer Reviewer:
Prof Cathy Jackson
Document ID:
13903 (v2)
Last Checked:
08/05/2015
Next Review:
07/05/2018
The Information Standard - certified member

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