Bone Tumours Benign, Malignant, Symptoms, and Treatment
Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Primary Bone Cancer article more useful, or one of our other health articles.
Treatment of almost all medical conditions has been affected by the COVID-19 pandemic. NICE has issued rapid update guidelines in relation to many of these. This guidance is changing frequently. Please visit https://www.nice.org.uk/covid-19 to see if there is temporary guidance issued by NICE in relation to the management of this condition, which may vary from the information given below.
Bone tumours include both benign and malignant lesions:
- Benign lesions may cause pain, expansion into local structures, and joint dysfunction, and predispose to pathological fractures.
- Secondary malignant tumours are much more common than primary malignant bone tumours. Bone is the most frequent site for metastasis for many cancers, particularly breast cancer and prostate cancer.
Types of bone tumours
- Bone: osteoid osteoma.
- Cartilage: chondroma, osteochondroma.
- Fibrous tissue: fibroma.
- Bone marrow: eosinophilic granuloma (see the separate article Langerhans' Cell Histiocytosis).
- Vascular: haemangioma.
- Uncertain: giant cell tumour.
- Bone: osteosarcoma.
- Cartilage: chondrosarcoma.
- Fibrous tissue: fibrosarcoma.
- Bone marrow: Ewing's sarcoma, myeloma.
- Vascular: angiosarcoma.
- Uncertain: malignant giant cell tumour.
Types of benign bone tumour
- Usually less than 1 cm in diameter and surrounded by dense osteoid.
- Often occurs in young adults.
- Most common sites are the tibia, femur and vertebrae.
- Presents with pain, which is often worse at night and relieved by non-steroidal anti-inflammatory drugs.
- X-ray has the characteristic appearance of a radiolucency surrounded by dense bone.
- Local excision is curative.
- One of the most common benign bone tumours.
- Sessile or pedunculated lesions arising from the cortex of a long bone adjacent to the epiphyseal plate.
- Lesions can be single or multiple.
- Often presents in adolescence as cartilaginous overgrowth at epiphyseal plate.
- Grows with the underlying bone.
- Presents as a painless lump or occasionally joint pain.
- Excision should be considered if it is causing significant symptoms.
- Problems include nerve compression (especially peroneal nerve), ankle diastasis and angular deformities. Malignant transformation to low-grade chondrosarcoma is more common with multiple osteochondromas and more proximal lesions.
- Multiple hereditary exostosis is an autosomal-dominant disorder with a mild decrease in stature, normal intelligence and multiple osteochondromas. It is commonly accompanied by leg length discrepancy, knee and elbow angular deformities and other skeletal abnormalities.
- Lesions may be single or multiple (Ollier's disease).
- Appears in tubular bones of the hands and feet.
- X-ray shows a well-defined osteopenic area in the medulla.
- Lesion should be excised and bone grafted.
Giant-cell tumour (osteoclastoma)
- Represents about 20% of primary bone tumours.
- Aggressive, locally recurrent tumour with a low metastatic potential.
- Found in the sub-articular cancellous region of long bones. Most lesions occur in closed epiphyses around the knee joint and distal radius.
- Only occurs after closure of epiphyses.
- Patients are usually aged between 20 and 40 years. It is more common in females.
- X-ray shows an asymmetric rarefied area at the end of a long bone.
- Cortex is thinned or even perforated.
- Treatment is by local excision and grafting often leads to recurrence.
- The treatment of choice is wide excision and joint replacement.
- Amputation if there is malignant or recurrent tumour.
- Rare, normally in epiphysis of long bones - eg, the hip, shoulder and knee.
- Usually presents at age 10-19 years with pain in the joint, muscle atrophy and tenderness.
- Treatment is with curettage and bone grafting.
- Locally destructive progressive lesion commonly found in vertebrae.
- Usually presents with dull aching pain.
- Frequently needs biopsy to exclude malignancy.
- Treatment is with curettage/bone grafting or en bloc excision.
- These occur in 40% of children aged >2 years.
- Usually asymptomatic.
- Usually no treatment is required, except when it occupies >50% bone diameter when there is a need for curettage/bone grafting to avoid pathological fracture.
Unicameral bone cysts
- Fluid-filled lesion. It is rare before the age of 3 years and after skeletal maturity.
- They usually present as pathological fractures (asymptomatic before then) following relatively minor trauma, normally involving the proximal humerus or femur.
- Treatment is to allow a fracture to heal and then aspirate and inject with either methylprednisolone or bone marrow.
- Usually present before the age of 20, with pain and swelling.
- They are cavernous spaces filled with blood and solid lumps of tissue.
- They mainly affect the femur, tibia and spine, which may lead to cord or nerve root compression resulting in neurological symptoms.
- They grow rapidly and may be confused with malignancy.
- Treated with curettage/bone grafting or excision.
- There is recurrence in 20-30%, usually in the first 1-2 years after treatment and mainly in younger children.
- Fibrous replacement of cancellous bone - may be multiple or solitary, stable or progressive.
- Usually asymptomatic but, if involving the skull, may cause swelling or exophthalmos.
- Femoral involvement causes pain and a limp. May also cause limb length discrepancy, bowing and pathological fractures.
- Presents in children aged 1-10 years.
- Usually involves the tibia with anterior swelling or enlargement of the leg. Usually painless.
- Treatment is with excision and bone grafting, delayed until after the age of 10 years because of the high risk of recurrence if younger.
- Most common in boys aged 5-10 years; usually occurs before the age of 30.
- Most often affects the skull with local pain and swelling, marked tenderness and warmth in the area.
- Treatment is with curettage/bone grafting, low-dose radiotherapy or steroid injection.
Malignant bone tumours
- The most common primary bone malignancy in children.
- Osteosarcoma is the most common bone sarcoma (incidence: 0.3/100,000/year). The incidence is higher in adolescents but there is a significant second peak in the seventh and eighth decades of life. The male to female ratio is 1.4:1.
- In later life, it is seen associated with Paget's disease of bone.
- Occurs in the metaphyses of long bones. The most common sites are around the knee (75%) or proximal humerus.
- Often presents as a relatively painless tumour.
- Destroys bone and spreads into the surrounding tissue. Rapidly metastasises to the lung.
- X-ray shows combination of bone destruction and formation. Soft tissue calcification produces a 'sunburst' appearance.
- Management includes surgical resection of all gross disease in conjunction with systemic chemotherapy to control micro-metastatic disease.
- The five-year event-free survival is approximately 70% for patients with localised osteosarcoma. Patients with metastatic or recurrent disease have overall survival rates of less than 20%.
- Adverse prognostic factors include primary metastases, axial or proximal extremity tumour site, large tumour volume, elevated serum alkaline phosphatase or LDH levels and older age.
- This is a primitive neuroectodermal tumour (PNET) thought to arise from mesenchymal stem cells.
- Ewing's sarcoma is the third most common bone sarcoma (incidence: ∼0.1/100,000/year) and occurs most frequently in children and adolescents but is also seen in adults.
- There is a male predominance. The most common primary sites are the extremity bones (50%), followed by pelvis, ribs and vertebra. However, any bone can potentially be affected, and a soft tissue origin is also possible, especially in adults.
- It usually presents as a mass or swelling - most commonly in the long bones of the arms and legs, pelvis or chest but also in the skull and flat bones of the trunk. Other symptoms and signs include pain in the area of the tumour, redness in the area surrounding the tumour, malaise, anorexia, weight loss, fever (a poor prognostic sign), paralysis and/or incontinence if affecting the spine, and numbness or tingling as a result of nerve compression by the tumour.
- X-ray of the affected bone shows bone destruction with overlying onion-skin layers of periosteal bone formation.
- Biopsy of the tumour site is used for diagnosis.
- Molecular pathology techniques can be used on fresh, frozen formalin-fixed paraffin-embedded tissues.
- FBC and lactic dehydrogenase (LDH) measurement - anaemia and raised LDH levels at diagnosis suggest the presence of metastases and are an indication of a poor prognostic outcome.
- CT/MRI scanning is used to assess the extent of disease and the local structures involved.
- Bone scintigraphy is useful in identifying metastases and assessing response to treatment.
- Staging of the tumour is undertaken to determine the treatment and also give some indication of the likely prognosis:
- Stage IA - low-grade tumour found only within the hard coating of the bone.
- Stage IB - low-grade tumour extending locally into the soft tissues.
- Stage IIA - high-grade tumour found only within the hard coating of the bone.
- Stage IIB - high-grade tumour extending locally to the soft tissues.
- Stage III - low- or high-grade tumour which has metastasised.
- The family of a child with Ewing's sarcoma will require long-term support from a number of professionals in both primary care and the hospital setting. It is important that all members of the family know where to access information, support and practical help when required and it is vital that there is good communication between all professionals involved in the care of the child.
- Chemotherapy is usually the first line of treatment and is currently initiated using a combination of vincristine, ifosfamide, doxorubicin and etoposide (VIDE). The treatment usually takes the form of six courses of treatment at intervals of three weeks, following which further management decisions will be based partly on the response to treatment. Further courses of chemotherapy using different combinations of drugs are generally used following surgery or radiotherapy.
- Radiotherapy may be used in conjunction with surgery and/or chemotherapy. Radiotherapy may occasionally be used in place of surgery where removal of the bone is not possible - eg, in the spine. Some patients are treated with radiotherapy alone but one trial suggests that there is a higher rate of treatment failure and relapse compared to surgery.
- Peripheral blood stem cell harvest may be undertaken midway through chemotherapy. The recovered cells are stored in case of future need following further courses of chemotherapy. Allogenic stem cell transplantation may offer a way forward in refractory metastatic patients.
- Surgery is often required to remove the tumour. Limb-sparing surgery, where only a part of the bone is removed and replaced if necessary with a segment of prosthetic bone, is increasingly carried out, although amputation of the limb may be required if the tumour is affecting one of the long bones of the arm or leg. Physiotherapy ±/ prosthetic limb fitting may be required following surgery.
- Metastatic disease at presentation is the most significant predictor of survival. Approximately 25% of patients are diagnosed with metastatic disease (10% lung; 10% bones/bone marrow; 5% combinations or others). Multiple bone metastases confer a poorer outcome than lung/pleural metastases (below 20% compared with 50%-60% five-year survival).
- Other adverse known prognostic factors are tumour volume, LDH levels, axial localisation, older age (over 15 years), a poor histological response to pre-operative chemotherapy and incomplete or no surgery for primary site.
- With current recommended multimodal approaches including chemotherapy, five-year survival is 60%-75% in localised and 20%-40% in metastatic disease, depending on metastatic sites and tumour burden.
- Chondrosarcoma is the most frequent bone sarcoma of adulthood (incidence 0.2/100,000/year), with a median age at diagnosis between 30 and 60 years and no gender predominance.
- Dedifferentiated chondrosarcoma, mesenchymal chondrosarcoma and clear-cell chondrosarcoma are very rare chondrosarcoma subtypes.
- They may arise from pre-existing lesions (osteochondromas, chondromas) or they can be primary.
- They are usually associated with dull, deep pain.
- Radiographs may show invasiveness and soft tissue extension.
- Occurs in two forms:
- Central: tumour in the pelvis or proximal long bones.
- Peripheral: tumour in the cartilaginous cap of an osteochondroma.
- They tend to metastasise late.
- Wide local excision is often possible.
- Metastatic disease at presentation, histological grade, axial primary site and size have been reported as prognostic factors.
Spindle cell sarcomas
- These are a mixed group of malignant tumours including fibrosarcoma, malignant fibrous histiocytoma (MFH), leiomyosarcoma and undifferentiated sarcoma.
- They present between 30-60 years of age and men are more frequently affected than women.
- They are usually found in the metaphysis of long bones, present with pain and have a high incidence of fracture at presentation.
- The most common bone malignancies are metastatic carcinomas.
- They are usually multiple but may be solitary.
- The most common primaries are breast, prostate, lung, kidney and thyroid.
- Wilms' tumour and neuroblastoma are the most common metastatic lesions in childhood.
- Primary malignant bone tumours are rare.
- Secondary tumours are more common, especially in the elderly.
Bone tumour symptoms
- Most present with pain, swelling and localised tenderness.
- Rapid growth and erythema are suggestive of malignancy.
- They may cause pathological fractures.
- Plain X-ray.
- MRI and CT scan.
- Bone scan.
- Investigation of any occult primary lesion, especially breast, prostate, lung, kidney and thyroid.
Bone tumour treatment
- There may be considerable difficulty recognising tumours as malignant in non-specialised centres; therefore, all patients with a suspected primary malignant bone tumour should be referred to a bone sarcoma reference centre or an institution belonging to a specialised bone sarcoma network before biopsy.
- As malignant primary bone tumours are rare and management is complex, the accepted standard is treatment either in reference centres or within networks able to provide access to the full spectrum of care or shared with such centres within reference networks.
- If there is an existing pathological fracture in a possible primary malignant bone tumour, there is potential for dissemination of tumour cells into surrounding tissues which may increase the risk of local recurrence. In these patients there may be a strong case for immobilising the part following the biopsy, usually by application of an external splint.
- Internal fixation is contra-indicated, as it disseminates tumour further into both bone and soft tissues and also increases the risk of local recurrence. External splintage is recommended, along with appropriate pain control.
The purpose of follow-up is to detect either local recurrence or metastatic disease early enough that treatment is still possible and might be effective. It should include physical examination, imaging of the site and CXR or CT scan.
After completion of chemotherapy, patients should be seen every 6 weeks to 3 months for the first 2 years, every 2-4 months for years 3 and 4, every 6 months for years 5-10 and thereafter every 6-12 months according to local practice.
Further reading and references
Bone health in cancer; ESMO Clinical Practice Guidelines, European Society for Medical Oncology (2020)
Bone sarcoma statistics; Cancer Research UK
Sarcoma; NICE Quality Standard, January 2015
Denosumab for the prevention of skeletal-related events in adults with bone metastases from solid tumours; NICE Technology Appraisal Guidance, October 2012
Coleman RE, Croucher PI, Padhani AR, et al; Bone metastases. Nat Rev Dis Primers. 2020 Oct 156(1):83. doi: 10.1038/s41572-020-00216-3.
Ludwig JA; Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future. Curr Opin Oncol. 2008 Jul20(4):412-8.
Atif M, Ali Hasan OH, Ashraf U, et al; Benign tumours and tumour like lesions of bone. J Pak Med Assoc. 2018 Oct68(10):1502-1507.
Bone sarcomas: Clinical Practice Guidelines for diagnosis, treatment and follow-up; ESMO-EURACAN-GENTURIS-ERNPaedCan (2021)
Harrison DJ, Geller DS, Gill JD, et al; Current and future therapeutic approaches for osteosarcoma. Expert Rev Anticancer Ther. 2018 Jan18(1):39-50. doi: 10.1080/14737140.2018.1413939. Epub 2017 Dec 14.
Peersman B, Vanhoenacker FM, Heyman S, et al; Ewing's sarcoma: imaging features. JBR-BTR. 2007 Sep-Oct90(5):368-76.
Berkova A, Dundr P, Povysil C, et al; A comparision of RT-PCR and FISH techniques in molecular diagnosis of Ewing's sarcoma in paraffin-embedded tissue. Cesk Patol. 2008 Jul44(3):67-70.
Rodriguez-Galindo C, Liu T, Krasin MJ, et al; Analysis of prognostic factors in ewing sarcoma family of tumors: review of St. Jude Children's Research Hospital studies. Cancer. 2007 Jul 15110(2):375-84.
The stages of bone cancer; Cancer Research UK
Ewing's sarcoma in children; Macmillan Cancer Support
Indelicato DJ, Keole SR, Shahlaee AH, et al; Long-term clinical and functional outcomes after treatment for localized Ewing's tumor of the lower extremity. Int J Radiat Oncol Biol Phys. 2008 Feb 170(2):501-9. Epub 2007 Sep 12.
Lucas KG, Schwartz C, Kaplan J; Allogeneic stem cell transplantation in a patient with relapsed Ewing sarcoma. Pediatr Blood Cancer. 2008 Jul51(1):142-4.