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Important complications of anaesthesia

Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find the Death or brain damage from anaesthesia article more useful, or one of our other health articles.

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Anaesthesia is from the Greek and means 'loss of sensation'. Anaesthesia allows invasive and painful procedures to be performed with little distress to the patient.

There are three main types of anaesthesia.

General anaesthesia

The patient is sedated, using either intravenous medications or gaseous substances, and occasionally muscles paralysed, requiring control of breathing by mechanical ventilation.

Regional anaesthesia

This can be described as central where anaesthetic drugs are administered directly in or around the spinal cord, blocking the nerves of the spinal cord (eg, epidural or spinal anaesthesia). The main benefit of this method is that ventilation is not needed (provided the block is not too high). Regional anaesthesia can also be peripheral - for example:

  • Plexus blocks - eg, brachial plexus.

  • Nerve blocks - eg, femoral.

  • Intravenous blocks whilst preventing venous flow out of the region - eg, Bier's block.

Local anaesthesia

In this method the anaesthetic is applied to one site, usually topically or subcutaneously.

Important complications of general anaesthesia

The practice of anaesthesia is fundamental to the practice of medicine. However, anaesthesia is not without its problems. It is difficult to determine exactly the incidence of deaths directly attributable to general anaesthetics, as the cause of death is often multifactorial and study methodology varies making comparisons difficult.

In 1987 a confidential enquiry into perioperative deaths revealed that very few deaths were actually as a direct result of general anaesthesia - there was an incidence of 1 in 185,086 (first Confidential Enquiry into Perioperative Deaths (CEPOD)).1 More recently in a Swiss single tertiary centre data analysis between 2003 and 2019, 1.5 deaths occurred for every 100,000 patients.2

Figures of anaesthetic-related morbidity are more difficult to determine. Although general anaesthesia is not without risk, it should be remembered that it allows necessary procedures to be performed in a humane way - without which the patient might otherwise die.

Along these lines, if a patient is high-risk for a general anaesthetic (eg, pre-existing comorbidities) then they should still be referred for surgery like any other patient. The decision to operate and which form of anaesthesia to use should then be decisions made by the surgeon and anaesthetist.

Important complications of general anaesthesia

Important information


Nausea and vomiting - up to 30% of patients.3

Damage to teeth.4

Sore throat and laryngeal damage.

Anaphylaxis to anaesthetic agents - approximately 1 in 3,000.5

Cardiovascular collapse.

Respiratory depression.

Aspiration pneumonitis - non-obstetric emergency rate between 1 in 373 to 1 in 895.6


Hypoxic brain damage.

Nerve injury.7

Awareness during anaesthesia.

Embolism - air, thrombus, venous or arterial.



Idiosyncratic reactions related to specific agents - eg, malignant hyperpyrexia with suxamethonium, succinylcholine-related apnoea.

Iatrogenic - eg, pneumothorax related to central line insertion.


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Some specific complications of general anaesthesia


  • Anaphylaxis can occur to any anaesthetic agent and in all types of anaesthesia.5 The severity of the reaction may vary but features may include rash, urticaria, bronchospasm, hypotension, angio-oedema, and vomiting. It needs to be carefully looked for in the pre-operative assessment and previous general anaesthetic charts may help.

  • Patients who are suspected of an allergic reaction should be referred for further investigation to try to determine the exact cause. If necessary, this may involve provocation testing or skin prick testing and patients should be referred to local immunologists. Anaphylaxis needs to be promptly recognised and managed and patients should be advised to wear a medical emergency identification bracelet or similar once they recover.

Aspiration pneumonitis

  • A reduced level of consciousness can lead to an unprotected airway. If the patient vomits they can aspirate the vomitus contents into their lungs. This can set up lung inflammation with infection. The risk of aspiration pneumonitis and aspiration pneumonia is reduced by fasting for several hours prior to the procedure and cricoid cartilage pressure during induction of anaesthesia.6 However, the evidence for the use of cricoid pressure is not clearly documented and further investigation is required.

  • Other methods of reducing aspiration pneumonitis associated with anaesthesia are the use of metoclopramide to enhance gastric emptying or proton pump inhibitors to increase the pH of gastric contents.

  • Aspiration pneumonitis may also occur in spinal anaesthesia if the level of spinal block is too high, leading to paralysis or impairment of the vocal cords and respiratory impairment.

Peripheral nerve damage

  • This can occur with all the types of anaesthesia and results from nerve compression. The most common cause is exaggerated positioning for prolonged periods of time. Both the anaesthetist and the surgeons should be aware of this potential complication and patients should be moved on a regular basis if possible. The severity varies and recovery may be prolonged. The most common nerves affected are the ulnar nerve and the common peroneal nerve. More rarely, the brachial plexus may be affected.

  • Injury to nerves can be avoided by prevention of extreme postures for lengthy periods during surgery. If nerve damage occurs then patients should be followed up and further investigations such as electromyography may be required.

Damage to teeth4

It is now common practice to check the teeth in the anaesthetist's pre-operative assessment. Damage to teeth is actually the most common cause of claims made against anaesthetists. In a 2023 systematic review and meta-analysis, during the peri-operative period, the majority of dental injuries (50–75%) occur during tracheal intubation.4 The overall incidence of dental injury is estimated to be between 0.06% and 12%, but these values may be underestimated. The tooth most commonly affected is the upper left incisor.


Embolism is rare during an anaesthetic but is potentially fatal. Air embolism occurs more commonly during neurosurgical procedures or pelvic operations. Prophylaxis of thromboembolism is common and begins pre-operatively with thromboembolic deterrents (TEDS) and low molecular weight heparin (LMWH).

Important complications of regional anaesthesia

Central regional anaesthesia was first used at the end of the 18th century. It provided a method of blocking afferent and efferent nerves by injecting anaesthetic agents in either the epidural space around the spinal cord (epidural anaesthesia) or directly in the cerebrospinal fluid surrounding the spinal cord (ie in the subarachnoid space called spinal anaesthesia).

All nerves are blocked including motor nerves, sensory nerves and nerves of the autonomic system. Epidural anaesthesia takes slightly longer than spinal anaesthesia to take effect and provides predominantly analgesic properties. With both, the need for muscle paralysis and ventilation is not usually required but there is a risk that a high block will impair respiration, meaning that ventilation will be necessary.

A 2017 Cochrane systematic review showed that regional anaesthesia is associated with reduced mortality and reduction in serious complications in comparison with general anaesthesia.8 However, a 2022 systematic review and meta-analysis of RCTs comparing outcomes in those having general anaesthetic or spinal anaesthetic showed that spinal anaesthesia reduced the risk of acute kidney injury compared with GA: RR=0.59 (95% CI, 0.39-0.89), but there were no significant differences in the risk of other outcomes.9

Important complications of regional anaesthesia

Important information

Pain - patients may still experience pain despite spinal anaesthesia.

Post-dural headache from cerebrospinal fluid (CSF) leak.10

Hypotension and bradycardia through blockade of the sympathetic nervous system.

Limb damage from sensory and motor block.

Epidural or intrathecal bleed.

Respiratory failure if block is 'too high'.11

Direct nerve damage.


Damage to the spinal cord - may be transient or permanent.

Spinal infection.

Aseptic meningitis.

Haematoma of the spinal cord - enhanced by use of LMWH pre-operatively.


Urinary retention.

Spinal cord infarction.

Anaesthetic intoxication.

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Some specific complications of regional anaesthesia

Post-dural puncture headache

  • Post-dural puncture headache is very common after spinal anaesthesia and especially in young adults and obstetrics. Unintentional dural puncture occurs in 0.15-1.5% of labour epidural analgesia and 50-80% of these women develop post-dural puncture headache.10

  • The headache results from CSF leak from the puncture site. It is increased by use of larger-gauge needles and reduced by atraumatic needles.12 Presenting symptoms may include headache, photophobia, vomiting and dizziness.

  • Post-dural puncture headache is usually treated with analgesia, bed rest and adequate hydration. Occasionally epidural blood patch is used where 15 ml of the patient's blood are injected at the site of the meningeal tear. Caffeine is also used and acts as a stimulant of the CNS and has shown benefit.13 Other medications with benefit include gabapentin, theophylline and hydrocortisone.

Total spinal block

Total spinal block can occur with the injection of large amounts of anaesthetic agents into the spinal cord. It is detected by a high sensory level and rapid muscle paralysis. The block moves up the spinal cord so that respiratory embarrassment may occur, as can unconsciousness. In these situations the patient needs prompt assessment and may need to be intubated and ventilated until the spinal block wears off. The quoted incidences vary between 1 in 2,971 and 1 in 16,200 anaesthetics.14


  • Hypotension during spinal anaesthesia for elective caesarean delivery occurs in as many as 70% to 80% of women receiving pharmacological prophylaxis.15 They develop transient hypotension as sympathetic nerves are blocked. This usually responds to prompt fluid replacement, usually starting with crystalloids followed by colloids. Occasionally hypotension can be severe and may require vasopressors along with fluids.

  • Care must be taken in patients with a cardiac history, as they may develop myocardial ischaemia with minor drops in blood pressure. It is suggested that heart rate variability prior to spinal anaesthesia represents autonomic dysfunction and may help determine patients who are more likely to develop hypotension.

  • Cases of bradycardia with asystole leading to cardiac arrest have also occurred and it appears the underlying aetiology is complicated and not just related to autonomic dysfunction.

Neurological deficits

  • Cauda equina syndrome may occur and can be transient or permanent. This is a common reason for patients to refuse spinal anaesthesia. There may also be traumatic injury to the spinal cord.

  • Adhesive arachnoiditis is a longer-term sequela of spinal anaesthesia, occurring weeks and even months later. It is characterised by proliferation of the meninges and vasoconstriction of spinal cord blood vessels. This results in gradual sensory and motor deficits from ischaemia and infarction of the spinal cord.

Important complications of local anaesthesia

  • Pain.

  • Bleeding and haematoma formation.

  • Nerve injury due to direct injury.

  • Infection.

  • Ischaemic necrosis.

All forms of anaesthetics are invasive to a patient and therefore consent should be obtained as for other procedures. Ideally patients should be given a leaflet regarding anaesthesia and then counselled regarding the intended benefits and the risks of anaesthesia.

In a general practice setting it will be the responsibility of the clinician who administers the local anaesthesia to ensure fully informed, non-coercive consent is obtained.

Further reading and references

  • Schittek GA, Schwantzer G, Zoidl P, et al; Adult patients' wellbeing and disturbances during early recovery in the post anaesthesia care unit. A cross-sectional study. Intensive Crit Care Nurs. 2020 Dec;61:102912. doi: 10.1016/j.iccn.2020.102912. Epub 2020 Aug 14.
  • Cook TM, Woodall N, Frerk C; Major complications of airway management in the UK: results of the Fourth National Audit Project of the Royal College of Anaesthetists and the Difficult Airway Society. Part 1: anaesthesia. Br J Anaesth. 2011 May;106(5):617-31. doi: 10.1093/bja/aer058. Epub 2011 Mar 29.
  1. Aitkenhead AR; Injuries associated with anaesthesia. A global perspective.; Br J Anaesth. 2005 Jul;95(1):95-109. Epub 2005 May 20.
  2. Gehrer F, Hansen D, Konrad CJ; Anaesthesia related complications - a single centre data analysis at a tertiary hospital in central Switzerland. Swiss Med Wkly. 2022 Jun 24;152:w30169. doi: 10.4414/smw.2022.w30169. eCollection 2022 Jun 20.
  3. Sizemore DC, Grose BW; Postoperative Nausea. StatPearls, Nov 2022.
  4. Neto JM, Teles AR, Barbosa J, et al; Teeth Damage during General Anesthesia. J Clin Med. 2023 Aug 17;12(16):5343. doi: 10.3390/jcm12165343.
  5. Patton K, Borshoff DC; Adverse drug reactions. Anaesthesia. 2018 Jan;73 Suppl 1:76-84. doi: 10.1111/anae.14143.
  6. Salik I, Doherty TM; Mendelson Syndrome. StatPearls Publishing; 2019.
  7. Hewson DW, Bedforth NM, Hardman JG; Peripheral nerve injury arising in anaesthesia practice. Anaesthesia. 2018 Jan;73 Suppl 1:51-60. doi: 10.1111/anae.14140.
  8. Van Waesberghe J, Stevanovic A, Rossaint R, et al; General vs. neuraxial anaesthesia in hip fracture patients: a systematic review and meta-analysis. BMC Anesthesiol. 2017 Jun 28;17(1):87. doi: 10.1186/s12871-017-0380-9.
  9. Kunutsor SK, Hamal PB, Tomassini S, et al; Clinical effectiveness and safety of spinal anaesthesia compared with general anaesthesia in patients undergoing hip fracture surgery using a consensus-based core outcome set and patient-and public-informed outcomes: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. 2022 Nov;129(5):788-800. doi: 10.1016/j.bja.2022.07.031. Epub 2022 Sep 28.
  10. Buddeberg BS, Bandschapp O, Girard T; Post-dural puncture headache. Minerva Anestesiol. 2019 May;85(5):543-553. doi: 10.23736/S0375-9393.18.13331-1. Epub 2019 Jan 4.
  11. Martinez-Velez A, Singh P; Epidural Morphine. StatPearls Publishing; 2023.
  12. Arevalo-Rodriguez I, Munoz L, Godoy-Casasbuenas N, et al; Needle gauge and tip designs for preventing post-dural puncture headache (PDPH). Cochrane Database Syst Rev. 2017 Apr 7;4:CD010807. doi: 10.1002/14651858.CD010807.pub2.
  13. Basurto Ona X, Osorio D, Bonfill Cosp X; Drug therapy for treating post-dural puncture headache. Cochrane Database Syst Rev. 2015 Jul 15;(7):CD007887. doi: 10.1002/14651858.CD007887.pub3.
  14. Asfaw G, Eshetie A; A case of total spinal anesthesia. Int J Surg Case Rep. 2020;76:237-239. doi: 10.1016/j.ijscr.2020.09.177. Epub 2020 Sep 29.
  15. Chooi C, Cox JJ, Lumb RS, et al; Techniques for preventing hypotension during spinal anaesthesia for caesarean section. Cochrane Database Syst Rev. 2020 Jul 1;7(7):CD002251. doi: 10.1002/14651858.CD002251.pub4.

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The information on this page is written and peer reviewed by qualified clinicians.

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