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Intestinal obstruction and ileus

Medical Professionals

Professional Reference articles are designed for health professionals to use. They are written by UK doctors and based on research evidence, UK and European Guidelines. You may find one of our health articles more useful.

The term ileus is now most often used to imply non-mechanical intestinal obstruction. The term paralytic ileus is sometimes used when the problem is inactivity of the bowel.

NB: obstruction to free passage of contents can occur at any level of the gut but only obstruction beyond the duodenum will be considered here. For conditions causing obstruction at a higher level, see the separate articles on Oesophageal Strictures, Webs and Rings, Oesophageal Cancer, Gastric Cancer and Infantile Hypertrophic Pyloric Stenosis.

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Of all patients admitted to hospital with intestinal obstruction, most have small intestinal obstruction. Significant numbers of colorectal malignancies present with obstruction.

Volvulus, impaction of the intestine, constipation and megacolon are all more common in patients with presenile dementia and Alzheimer's disease, Parkinson's disease, multiple sclerosis and quadriplegia. Schizophrenia has an increased risk for megacolon and constipation whilst major depression is associated only with constipation but with none of the other colonic diseases.

Risk factors

  • Small intestinal obstruction:

    • May be due to adhesions, strangulated hernia, malignancy or volvulus. The majority (75%) of small bowel obstructions are attributed to intra-abdominal adhesions from prior operations1.

    • Malignancy usually means a tumour of the caecum, as small bowel malignancies are very rare2.

  • Large intestinal obstruction:

    • Is most often the result of colorectal malignancies. Patients are often aged over 70.

    • The risk of obstruction increases the further down the bowel the lesion is sited, as the contents become more solid.

    • Tumours are often advanced and there may be distant metastases.

    • Perforation can occur at the site of the tumour or in a dilated caecum3.

  • Sigmoid and caecal volvulus:

    • Describes rotation of the gut on its mesenteric axis. The sigmoid colon is the most common site of volvulus and accounts for 5% of large bowel obstruction.

    • It is usually seen in the elderly or those with psychiatric illness.

    • It is the most common cause of intestinal obstruction in Africa and Asia, where the incidence is 10 times higher than in Europe or North America4.

  • Paralytic ileus describes the condition in which the bowel ceases to function and there is no peristalsis. Intestinal pseudo-obstruction is also called Ogilvie's syndrome. It results from massive dilatation of the colon but possibly small intestine too. It may occur in association with a number of medical conditions including5:

    • Chest infection

    • Acute myocardial infarction

    • Stroke

    • Acute kidney injury

    • Puerperium

    • Trauma

    • Severe hypothyroidism

    • Electrolyte disturbance

    • Diabetic ketoacidosis

  • Postoperative ileus is a significant problem. Reduced handling of the bowel at operation is recommended.

  • Congenital gastrointestinal malformations can cause neonatal intestinal obstruction. Another cause of meconium ileus is cystic fibrosis. Volvulus and midgut malrotations affect children and are uncommon6.

  • Hirschsprung's disease can cause blockage of the bowel. It may present early or late in childhood. Intussusception in children blocks the bowel. Intussusception in adults is much less common and does not tend to obstruct7.

  • Miscellaneous causes in adults include gallstone ileus (which occurs when a large gallstone is passed into the gut and blocks it), severe constipation causing faecal impaction, and Crohn's disease. Malignancy may cause obstruction from outside the gut - eg, gynaecological tumours.

  • Bezoars - eg, medication bezoars (tablets or semi-liquid masses of medications, most often formed following overdose of sustained-release medications) and trichobezoars (a bezoar formed from hair).

  • Body packers can develop intestinal obstruction when packets of illicit drugs packed in condoms are swallowed and trapped in the bowel. The packages may be visible on X-ray. If they leak, intoxication will occur8.


The typical clinical symptoms associated with obstruction include nausea, vomiting, dysphagia, abdominal pain and failure to pass bowel movements. Clinical signs include abdominal distention, tympany due to an air-filled stomach and high-pitched bowel sounds9.


There is considerable overlap with the presentation of the various conditions although some features may be more prominent or occur earlier in one cause than another. Differentiation on clinical grounds alone is often not possible.

  • Diffuse, central abdominal pain of a colicky nature. Pain is less or absent in paralytic ileus but there may be a history to suggest causes.

  • Vomiting tends to be early in high-level obstruction. Faeculent vomiting is extremely unpleasant and is limited to low obstruction. Retrograde peristalsis results in faecal material being brought back.

  • The progress of the condition tends to be faster in small bowel obstruction and slower with lower levels of lesions.

  • Abdominal distension: the lower the level of obstruction, the more marked this will be.

  • Absolute constipation is early in low obstruction and late in high-level obstruction. In low-level obstruction there may be a history of progressive constipation or change in bowel habit. In paralytic ileus there is no bowel movement and no flatus.

  • In sigmoid volvulus the picture is rather like large bowel obstruction with pain, constipation, late vomiting and a very marked degree of abdominal distension. Half of such patients will have had a previous episode4.

  • Colonic pseudo-obstruction:

    • Occurs when there is an autonomic imbalance resulting in sympathetic over-activity affecting some part of the colon. The patient is often elderly with numerous comorbidities10.

    • Pseudo-obstruction presents like a large bowel obstruction but the other medical history may indicate the true nature5.

  • Severe pain and tenderness suggest ischaemia or perforation.


  • Look for signs of dehydration such as poor peripheral perfusion, tachycardia and hypotension. Dehydration is caused by water remaining unabsorbed in the bowel and losses from vomiting without the ability to replace orally. Pyrexia may suggest perforation or infarction of the bowel.

  • Examination of the abdomen starts with observation. Abdominal distension will be apparent. It may be worth measuring abdominal girth to monitor progress. Massive peristalsis may even by visible.

  • Distended bowel is very resonant on percussion. Abdominal masses may possibly be felt but even a large mass may be missed in a grossly distended abdomen.

  • If strangulation or perforation occurs there will be features of an acute abdomen with peritonism.

  • Check hernial orifices. Femoral hernia is at high risk of obstruction. Inguinal hernia is a lower risk factor but it is much more common.

  • Place a stethoscope on the abdomen to listen for bowel sounds. In obstruction they are very active and tinkling bowel sounds are characteristic. In ileus the bowel is silent or nearly so. Bowel sounds are very irregular and so auscultation must not be rushed if a true picture is to be achieved.

  • The patient may be generally toxic and unwell because ischaemia of the bowel allows bacteria and toxins to enter the circulation.

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  • Fluid charts are required to monitor intake and output, especially as an intravenous infusion is almost certainly required, a nasogastric tube may be passed and oliguria is an important sign of early dehydration.

  • Plain abdominal X-ray is an important investigation although proximal small bowel obstruction may be overlooked if there is no gas in the small bowel:

    • Sensitivity is 50-66%. Films are taken supine and erect. A systematic approach is required.

    • Obstruction of the small bowel shows ladder-like series of small bowel loops but this also occurs with an obstruction of the proximal colon. Fluid levels in the bowel can be seen in upright views.

    • Distended loops may be absent if obstruction is at the upper jejunum.

    • The colon is in the more peripheral part of the film and distension may be very marked.

    • Fluid levels will also be seen in paralytic ileus and the small bowel is distended throughout its length. In an erect film a fluid level in the stomach is normal as may be a level in the caecum.

    • Multiple fluid levels and distension of the bowel are abnormal. Gas under the diaphragm suggests perforation.

  • Blood should be taken for FBC, U&Es and creatinine and group and cross-match, as major surgery may be required. Glucose may be slightly elevated by stress but very high levels are a cause for concern.

  • If there is doubt about a low-level obstruction, a water-soluble contrast enema X-ray may be helpful in diagnosis. A meta-analysis concluded that there was a small reduction in the duration of hospital stays, but no significant impact on operation or mortality rates11.

  • CT scanning:

    • Has been used to good effect to predict the need for surgery in small bowel obstruction12.

    • Non-contrast CT is recommended if the index of suspicion is high or if suspicion persists despite normal X-rays13.

    • Patients with peritoneal fluid evident on CT scan are three times more likely to require surgical intervention than those who do not have this sign.

    • Partial obstruction may not be detected on CT and suspicion should remain high if the clinical picture suggests obstruction despite a normal scan.

  • Both MRI and ultrasound have been found useful in the diagnosis of small bowel obstruction. MRI is more expensive and less available. Portable ultrasound machines can be used at the bedside and are becoming increasingly popular. They have a sensitivity of 95% and specificity of 84% in diagnosing small bowel obstruction1415.

Differential diagnosis

  • Abdominal pain and vomiting can occur with gastroenteritis but, if the abdomen is bloated and there is little or no bowel movement, obstruction must be considered. Diarrhoea and vomiting will also cause very active bowel sounds that may be confused with the tinkling of obstruction

  • Ischaemia of the gut can cause pain and distension but there is usually bloody diarrhoea.

  • The pain of acute pancreatitis tends to radiate to the back. There may be an associated paralytic ileus. Amylase is often raised in obstruction but levels are very high in pancreatitis.

  • Perforation of the gut can produce an acute abdomen with pyrexia and vomiting. Peptic ulcer disease, perforated diverticular disease and a perforated carcinoma are all possible causes.

  • Intussusception should be considered in children.

  • Tuberculosis can present as gastrointestinal disease.

  • Non-gastrointestinal conditions to bear in mind include myocardial infarction (small bowel) and ovarian cancer (large bowel).

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In patients with uncomplicated obstruction, management is conservative, including fluid resuscitation, electrolyte replacement, intestinal decompression and bowel rest. Endoscopy can be used for bowel decompression, dilation of strictures or placement of self-expandable metal stents to restore the luminal flow either as a final treatment or to allow for a delay until elective surgical therapy. When gastrointestinal obstruction results in ischaemia, perforation or peritonitis, then emergency surgery is required9.

Resuscitation is very important. Correction of fluid and electrolytes considerably reduces the operative risk before surgery for obstruction. In pseudo-obstruction, correction of such abnormalities will facilitate the return of normal bowel function. Note urine output as a sign of adequate replacement. In paralytic ileus a nasogastric tube will reduce vomiting.


  • Laparotomy may be required without a clear diagnosis. Resection of the bowel may be required and so blood must be cross-matched and available. Informed consent before the operation should include the fact that a stoma may be required.

  • If possible, it is worth awaiting full resuscitation and fluid replacement before surgery but if the patient is toxic with possible perforation or infarction of bowel, early intervention is required.

  • Early surgery is required if there is local or generalised peritonitis, evidence of perforation or an irreducible hernia. A palpable mass and failure to improve are relative indications to intervene surgically.

  • A more conservative approach is acceptable if there is incomplete obstruction, previous surgery suggesting adhesions, advanced malignancy or suggestion that it is pseudo-obstruction.

  • In view of the risk of perforation and absorption of toxins from ischaemic bowel, prophylactic antibiotics for gut surgery are advised.

Non-surgical treatment

  • Endoscopic stenting is a further advance in the management of small and large bowel obstruction and may be particularly useful in the palliative care of cancer patients and in the elderly1617. Self-expanding stents are of particular value in the management of obstruction of the large bowel18.

  • If adhesions are thought to be the cause of obstruction then conservative measures may be sufficient.


See also the separate Volvulus and Midgut Malrotations article.

  • Sigmoid volvulus can be treated conservatively in many cases. Sigmoidoscopy and passage of a flatus tube may be successful. Failure of decompression or evidence of perforation requires operation.

  • Around 25% of colonic volvulus is of the caecum. It involves the terminal ileum and ascending colon. Decompression via the colonoscope may work but usually surgery is required. Ischaemic bowel may require resection. Fixation prevents recurrence.

  • Caecal volvulus is an uncommon and poorly recognised condition19. There may be a history of previous, intermittent, self-limiting abdominal pain.


In intestinal pseudo-obstruction the cautious use of neostigmine may aid recovery but most important is the correction of fluid and electrolyte imbalance20. Colonoscopy may need to be used for decompression. Early recognition and management are vital if perforation is to be avoided21.

Malignant bowel obstruction

See also the separate Colorectal Cancer article.

  • The management of patients with obstruction due to malignancy who are unfit for surgery provides considerable problems. Corticosteroids, opioids, antispasmodics, antiemetics and antisecretory agents may all be of benefit22.

  • One review (based only on a few studies) regarding colonic stenting for malignant large bowel obstruction found23:

    • Although emergency colonic stenting appears to be an effective treatment of malignant large bowel obstruction, there were no advantages in terms of overall complication rate and 30-days postoperative mortality.

    • However, when colonic stenting was used as a bridge to surgery, it provided surgical advantages, a higher primary anastomosis rate and a lower overall stoma rate, without increasing the risk of anastomotic leak or intra-abdominal abscess. However, these results should be interpreted with caution because few studies reported data on these outcomes.


  • Carcinomas causing obstruction are usually primary small or large bowel cancers. Metastases from other organs are rare24.

  • Perforation and ischaemia of the bowel may cause peritonitis and septicaemia.

  • Fluid and electrolyte imbalance, hypovolaemia and septicaemia may all contribute to circulatory collapse and acute kidney injury.

  • In acute colonic pseudo-obstruction, if perforation or ischaemia occurs the mortality is 40%25.


  • In patients with small bowel obstruction, the mortality is 14% if surgery is delayed, compared to 3% if this is performed immediately26.

  • The prognosis of advanced carcinoma of the colon remains poor. A high proportion of patients who present with obstruction have distant metastases27.

  • 50% of sigmoid volvulus will recur in the following two years.

  • Older patients, patients with hypoalbuminaemia and those in whom the primary tumour is not gastrointestinal in origin are less able to withstand the rigours of major surgery28.

Further reading and references

  1. Sarraf-Yazdi S, Shapiro ML; Small bowel obstruction: the eternal dilemma of when to intervene. Scand J Surg. 2010;99(2):78-80.
  2. Small Bowel Obstruction; Surgical Tutor
  3. Large bowel obstruction; Surgical Tutor
  4. Sigmoid and caecal volvulus; Surgical Tutor
  5. Colonic pseudo-obstruction; Surgical Tutor
  6. Neonatal intestinal obstruction; Surgical Tutor
  7. Hirschsprung's Disease; Surgical Tutor
  8. East JM; Surgical complications of cocaine body-packing: a survey of Jamaican hospitals. West Indian Med J. 2005 Jan;54(1):38-41.
  9. Hucl T; Acute GI obstruction. Best Pract Res Clin Gastroenterol. 2013 Oct;27(5):691-707. doi: 10.1016/j.bpg.2013.09.001. Epub 2013 Sep 15.
  10. Durai R; Colonic pseudo-obstruction. Singapore Med J. 2009 Mar;50(3):237-44.
  11. Koh A, Adiamah A, Chowdhury A, et al; Therapeutic Role of Water-Soluble Contrast Media in Adhesive Small Bowel Obstruction: a Systematic Review and Meta-Analysis. J Gastrointest Surg. 2020 Feb;24(2):473-483. doi: 10.1007/s11605-019-04341-7. Epub 2019 Aug 13.
  12. Jones K, Mangram AJ, Lebron RA, et al; Can a computed tomography scoring system predict the need for surgery in small-bowel obstruction? Am J Surg. 2007 Dec;194(6):780-3; discussion 783-4.
  13. Jackson PG, Raiji MT; Evaluation and management of intestinal obstruction. Am Fam Physician. 2011 Jan 15;83(2):159-65.
  14. Khan MAB, Abu-Zidan FM; Point-of-care ultrasound for the acute abdomen in the primary health care. Turk J Emerg Med. 2020 Jan 28;20(1):1-11. doi: 10.4103/2452-2473.276384. eCollection 2020 Jan-Mar.
  15. Lim TZ, Tan KK; Endoscopic stenting in colorectal cancer. J Gastrointest Oncol. 2019 Dec;10(6):1171-1182. doi: 10.21037/jgo.2019.02.15.
  16. Olmi S, Scaini A, Cesana G, et al; Acute colonic obstruction: endoscopic stenting and laparoscopic resection. Surg Endosc. 2007 Nov;21(11):2100-4. Epub 2007 May 4.
  17. Caceres A, Zhou Q, Iasonos A, et al; Colorectal stents for palliation of large-bowel obstructions in recurrent gynecologic cancer: An updated series. Gynecol Oncol. 2008 Jan 9.
  18. Dronamraju SS, Ramamurthy S, Kelly SB, et al; Role of self-expanding metallic stents in the management of malignant obstruction of the proximal colon. Dis Colon Rectum. 2009 Sep;52(9):1657-61.
  19. Consorti ET, Liu TH; Diagnosis and treatment of caecal volvulus. Postgrad Med J. 2005 Dec;81(962):772-6.
  20. Ilban O, Cicekci F, Celik JB, et al; Neostigmine treatment protocols applied in acute colonic pseudo-obstruction disease: A retrospective comparative study. Turk J Gastroenterol. 2019 Mar;30(3):228-233. doi: 10.5152/tjg.2018.18193.
  21. Jeong SJ, Park J; Endoscopic Management of Benign Colonic Obstruction and Pseudo-Obstruction. Clin Endosc. 2020 Jan;53(1):18-28. doi: 10.5946/ce.2019.058. Epub 2019 Oct 24.
  22. Ferguson HJ, Ferguson CI, Speakman J, et al; Management of intestinal obstruction in advanced malignancy. Ann Med Surg (Lond). 2015 Aug 1;4(3):264-70. doi: 10.1016/j.amsu.2015.07.018. eCollection 2015 Sep.
  23. Cirocchi R, Farinella E, Trastulli S, et al; Safety and efficacy of endoscopic colonic stenting as a bridge to surgery in the management of intestinal obstruction due to left colon and rectal cancer: a systematic review and meta-analysis. Surg Oncol. 2013 Mar;22(1):14-21. doi: 10.1016/j.suronc.2012.10.003. Epub 2012 Nov 24.
  24. Lau CP, Hui EP, Chan AT; Complete small bowel obstruction caused by metastasis from primary nasopharyngeal carcinoma. Rare Tumors. 2009 Jul 22;1(1):e7. doi: 10.4081/rt.2009.e7.
  25. Saunders MD; Acute colonic pseudo-obstruction. Best Pract Res Clin Gastroenterol. 2007;21(4):671-87.
  26. Springer JE, Bailey JG, Davis PJ, et al; Management and outcomes of small bowel obstruction in older adult patients: a prospective cohort study. Can J Surg. 2014 Dec;57(6):379-84. doi: 10.1503/cjs.029513.
  27. Wang HS, Lin JK, Mou CY, et al; Long-term prognosis of patients with obstructing carcinoma of the right colon. Am J Surg. 2004 Apr;187(4):497-500.
  28. Medina-Franco H, Garcia-Alvarez MN, Ortiz-Lopez LJ, et al; Predictors of adverse surgical outcome in the management of malignant bowel obstruction. Rev Invest Clin. 2008 May-Jun;60(3):212-6.

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